细胞是组成生命的基本单位。在多细胞生物中，细胞分裂控制着细胞的数量，而细胞黏附则控制着细胞的形态和运动，二者的协同互作保证了多细胞生命体的稳态。尽管过去的研究已经为我们揭示了细胞周期和细胞黏附的核心调控网络，但二者之间协同互作的功能和机制仍有许多空白亟需填补。陈南鹏课题组致力于研究细胞在分裂，黏附和迁移中的行为及其分子机制，尤其关注细胞在增殖和癌变过程中所伴随的细胞黏附/迁移结构的巨大变化。实验室综合运用最前沿的显微技术，多组学和基因编辑技术，探索这些分子机制在三维环境和疾病进程中的生物学意义。

近期代表性论:

Nan-Peng Chen#; Jonas Aretz; Reinhard Fässler#; CDK1–cyclin-B1-induced kindlin degradation drives focal adhesion disassembly at mitotic entry, Nature Cell Biology, 2022, 24: 723-736. (#corresponding authors)(Faculty Opinions recommended: https://facultyopinions.com/article/742068317)

Nan-Peng Chen; Zhiqi Sun; Reinhard Fässler; The Kank family proteins in adhesion dynamics, Current Opinion In Cell Biology, 2018, 54(1): 130-136

Nan-Peng Chen; Borhan Uddin; Robert Hardt; Wen Ding; Marko Panic; Ilaria Lucibello; Patricia Kammerer; Thomas Ruppert; Elmar Schiebel; Human phosphatase CDC14A regulates actin organization through dephosphorylation of epithelial protein lost in neoplasm, PNAS, 2017, 114(20): 5201-5206

Nan-Peng Chen; Borhan Uddin; Renate Voit; Elmar Schiebel; Human phosphatase CDC14A is recruited to the cell leading edge to regulate cell migration and adhesion, PNAS, 2016, 113(4): 990-995

Borhan Uddin*; Nan-Peng Chen*; Marko Panic; Elmar Schiebel ; Genome editing through large insertion leads to the skipping of targeted exon, BMC genomics, 2015, 16(1): 1-10. (#co-first authors)

Patrick Partscht; Alexander Simon; Nan‐Peng Chen; Sylvia Erhardt; Elmar Schiebel; The HIPK2/CDC14B-MeCP2 axis enhances the spindle assembly checkpoint block by promoting cyclin B translation, Science Advances, 2023, 9(3)