探索微生物的免疫逃逸机制；

针对免疫逃逸机制开发免疫疗法（含疫苗和单抗）；

探索宿主影响抗体疗法的作用机理，开发适合于不同人群的疫苗和单抗；

抗生素耐药性的防治。（课题组网站：http://xinhaichen.szbl.ac.cn/）

近期代表性论文:

X Chen, H Gula, T Pius, C Ou, M Gomozkova, LX Wang, O Schneewind, D Missiakas*. Immunoglobulin G subclasses confer protection against Staphylococcus aureus bloodstream dissemination through distinct mechanisms in mouse models. PNAS, 2023, 120(14): e2220765120.

J Ye, X Chen*. Current Promising Strategies against Antibiotic-Resistant Bacterial Infections. Antibiotics, 2023; 12(1):67.

M Jiang, X Chen (Co-first author), H Li, XX Peng, B Peng*. Exogenous L-Alanine promotes phagocytosis of multidrug-resistant bacterial pathogens. EMBO Rep. 2023; 24(12): e49561.

X Chen, O Schneewind, D Missiakas*. Engineered human antibodies for the opsonization and killing of Staphylococcus aureus. PNAS, 2022, 119(4): e2114478119.

X Chen, M Shi, X Tong, HK Kim, LX Wang, O Schneewind, D Missiakas*. Glycosylation-dependent opsonophagocytic activity of Staphylococcal protein A antibodies. PNAS, 2020, 117(37): 22992-23000.

R Pang, H Zhou, Y Huang, Y Su*, X Chen*. Inhibition of host arginase activity against staphylococcal bloodstream infection by different metabolites. Front Immunol, 2020, 11, 1639.

X Chen, Y Sun, D Missiakas, O Schneewind*. Staphylococcus aureus decolonization of mice with monoclonal antibody neutralizing protein A. J Infect Dis, 2019, 219(6):884-888.