固有免疫信号通路（如cGAS-STING/ RIG-I-MAVS等）；肿瘤免疫；神经免疫；代谢与免疫。

1）固有免疫信号通路分子机制及其在神经系统疾病中的作用；

2）肿瘤免疫，尤其是代谢与肠道免疫在肿瘤中的作用及肿瘤免疫疗法的开发；

3）代谢与免疫的相互调控作用。

近期代表性论:

Ting-Ting Chu, Xintao Tu, Kun Yang, Jianjun Wu, Joyce J. Repa, Nan Yan. Tonic Prime-Boost of STING Signaling Mediates Niemann-Pick Disease Type C. (2021) Nature 596:570–575. 

Tu, X., Chu, TT., Jeltema, D. et al. Interruption of post-Golgi STING trafficking activates tonic interferon signaling. Nat Commun 13, 6977 (2022).

Qian-Qian Li, Yu-Qing Liu, Yun-Yi Luo, Ting-Ting Chu, Na Gao, Pu-Guang Chen, Yong-Xiang Chen and Yan-Mei Li. Uncovering the Pathological Functions of Ser404 Phosphorylation by Semi- synthesis of Phosphorylated TDP-43 Prion-Like Domain. (2020) Chem. Commun. 56:5370-5373. PMID: 32281994.

Na Gao, Yun-Peng Huang, Ting-Ting Chu, Qian-Qian Li, Bing Zhou, Yong-Xiang Chen, Yu-Fen Zhao and Ya-Mei Li. TDP-43 specific reduction induced by Di-hydrophobic tags conjugated peptides. (2019) Bioorg. Chem. 84:254-259. PMID: 30508770.

Na Gao, Ting-Ting Chu, Qian-Qian Li, Yeh-Jun Lim, Tian Qiu, Meng-Zhi-Wen Hu, Xi-Fei Yang, Yong-Xizng Chen, Yu-Fen Zhao and Yan-Mei Li. Hydrophobic tagging-mediated degradation of Alzheimer's disease related Tau. (2017) RSC Adv. 7:40362. DOI: 10.1039/c7ra05347a.

Lei Shi, Huai Chen, Si-Yu Zhang, Ting-Ting Chu, Yu-Fen Zhao, Yong-Xiang Chen, Yan-Mei Li.  Semi-synthesis of murine prion protein by native chemical ligation and chemical activation for preparation of polypeptide- α –thioester. (2017) J Pept Sci. 23:438-444. PMID: 28429419.

Ting-Ting Chu, Na Gao, Qian-Qian Li, Pu-Guang Chen, Xi-Fei Yang, Yong-Xiang Chen, Yu-Fen Zhao, Yan-Mei Li. Specific Knockdown of Endogenous Tau Protein by Peptide-directed Ubiquitin -Proteasome Degradation. (2016) Cell Chem. Biol. 23: 453-461. PMID: 27105281. (Cover article)

Ting-Ting Chu, Qian-Qian Li, Tian Qiu, Zhan-Yi Sun, Zhi-Wen Hu, Yong-Xiang Chen, Yu-Fen Zhao and Yan-Mei Li. Clearance of the intracellular high level of tau protein directed by artificial synthetic hydrolase. (2014) Mol. BioSyst. 10:3081-3085. PMID: 25308803.