细胞周期与基因组稳定性。课题组运用前沿的分子生物学、基因编辑以及活细胞高通量成像技术，结合体外生化重建、细胞和动物模型，研究在正常或病理条件下的细胞周期调控及其对基因组稳定性的影响，揭示癌症基因组进化过程中的信号转导途径，开发肿瘤治疗的新靶点、新药物和治疗新手段。

近期代表性论:

Wang, J., Xiong, J., Zhang, S., Li, D., Chu, Q., Chang, W., Deng, L.,* and Ji, W.* A complex containing RhoBTB3-SHIP164-Vps26B promotes the biogenesis of early endosome buds at Golgi-endosome contacts. Cell Discovery, 2024, https://doi.org/10.1101/2022.09.30.510409

Chen, H., Wang, Z., Gong, L., Wang, Q., Chen, W., Wang, J., Ma, X., Ding, R., Li, X., Zou, X., Plass, M., Lian, C., Ni, T., Wei, G., Li, W.,* Deng, L.,* and Li, L.* A distinct class of pan-cancer susceptibility genes revealed by alternative polyadenylation transcriptome-wide association study. Nature Communications, 2024, 15, 1729

Chu, Q., Wang, J., Du, Y., Zhou, T., Shi, A., Xiong, J.*, Ji, W.*, and Deng, L.* Oligomeric CHMP7 mediates three-way ER junctions and ER-mitochondria interactions. Cell Death & Differentiation, 2022, doi:10.1038/s41418-022-01048-2 PMID:35962186.

Deng, L., Wu, R.A., Sonneville, R., Kochenova, O.V., Labib, K., Pellman, D., and Walter, J.C. Mitotic CDK promotes replisome disassembly, fork collapse, and complex DNA rearrangements. Molecular Cell, 2019, 73(5):915-929.e6. PMID: 30849395.

Deng, L., Lee, M.E. Schutt K.L., and Moseley, J.B. Phosphatases generate signal specificity downstream of Ssp1 kinase in fission yeast. Molecular and Cellular Biology, 2017, 37:e00494-16.doi: 10.1128/MCB.00494-16. PMID: 28223368.

Deng, L., Baldissard, S., Kettenbach, A.N., Gerber, S.A., and Moseley, J.B. Dueling kinases regulate cell size at division through the SAD kinase Cdr2. Current Biology, 2014, 24, 428-433. PMID: 24508166.

Deng, L., Kabeche, R., Wang, N., Wu, J.Q., and Moseley, J.B. Megadalton node assembly by binding of Skb1 to the membrane anchor Slf1. Molecular Biology of the Cell, 2014, 25, 2660-2668. PMID: 25009287.

Deng, L., and Moseley, J.B. Compartmentalized nodes control mitotic entry signaling in fission yeast. Molecular Biology of the Cell, 2013, 24, 1872-1881. PMID: 23615447.