课题组将聚焦化学生物学这一前沿交叉领域，致力于功能化蛋白的进化和改造、蛋白质翻译后修饰调控工具的开发和应用，和细胞表面修饰和相互作用表征等方向的研究。利用所开发的以蛋白质为基础的化学生物学工具，结合蛋白质组学等研究手段，解析蛋白质包括糖基化在内的翻译后修饰在不同生理过程中的功能，为开发新的诊断和治疗策略等方面提供新思路。

近期代表性论:

Chen, Y.#; Wan, R.#; Zou, Z.#; Lao, L.; Shao, G.; Zheng, Y.; Tang, L.; Yuan, Y.; Ge, Y.*; He, C.*; Lin, S.*, O-GlcNAcylation determines the biological function of YTHDF proteins. Nat. Cell Biol., 2023, 25 (11), 1676-1690. 

Ge, Y.; Ramirez, D. H.; Yang, B.; D’Souza, A. K.; Aonbangkhen, C.; Wong, S.; Woo, C. M.*, Target protein deglycosylation in living cells by a nanobody-fused split O-GlcNAcase. Nat. Chem. Biol. 2021, 17 (5), 593-600. 

Ge, Y.#; Chen, L.#; Liu, S.; Zhao, J.; Zhang, H.; Chen, P. R.*, Enzyme-mediated intercellular proximity labeling for detecting cell-cell interactions. J. Am. Chem. Soc. 2019, 141 (5), 1833-1837. 

Liu, Y.#; Ge, Y.#; Zeng, R.#; Ngai, W. S.; Fan, X.*; Chen, P. R.*, Proximity Chemistry in Living Systems. CCS Chem. 2023, 5 (4), 802-813. 

Ge, Y.*; Lu, H.; Yang, B.; Woo, C. M.* Small Molecule-Activated O-GlcNAcase for Spatiotemporal Removal of O-GlcNAc in Live Cells. ACS Chem. Biol. 2023, 18 (1), 193-201.

Ge, Y.; Woo, C. M.*, Writing and erasing O-GlcNAc from target proteins in cells. Biochem. Soc. Trans. 2021, 49 (6), 2891-2901.