类器官是一种基于干细胞的体外组织和器官3D培养技术。人体来源类器官为人类生物学，疾病研究和药物开发提供了更加接近生理条件的实验体系。课题组致力于类器官医学研究，我们通过整合干细胞生物学，基因编辑，单细胞组学和组织工程等多学科技术，开发最先进的人源类器官疾病模型，特别是感染性疾病，癌症和罕见病，目标是将这些类器官疾病模型应用于揭示致病机理和开发新的治疗方案。

近期代表性论:

He, G. W.; Lin, L.; DeMartino, J.; Zheng, X.; Staliarova, N.; Dayton, T.; Begthel, H.; Wetering, W.; Bodewes, E.; Zon, J. E.; Tans, S.; Lopez-Iglesias, C.; Peters, P. J.; Wu, W.; Kotlarz, D.; Klein, C.; Margaritis, T.; Holstege, F.; Clevers, H., Optimized human intestinal organoid model reveals interleukin-22-dependency of Paneth cell formation. Cell Stem Cell 2022, 29(9):1333-1345. 

He, G. W.; Gunther, C.; Thonn, V.; Yu, Y. Q.; Martini, E.; Buchen, B.; Neurath, M. F.; Sturzl, M.; Becker, C., Regression of apoptosis-resistant colorectal tumors by induction of necroptosis in mice. J Exp Med 2017, 214 (6), 1655-1662.

He, G. W.; Gunther, C.; Kremer, A. E.; Thonn, V.; Amann, K.; Poremba, C.; Neurath, M. F.; Wirtz, S.; Becker, C., PGAM5-mediated programmed necrosis of hepatocytes drives acute liver injury. Gut 2017, 66 (4), 716-723.

Gunther, C.; He, G. W.; Kremer, A. E.; Murphy, J. M.; Petrie, E. J.; Amann, K.; Vandenabeele, P.; Linkermann, A.; Poremba, C.; Schleicher, U.; Dewitz, C.; Krautwald, S.; Neurath, M. F.; Becker, C.; Wirtz, S., The pseudokinase MLKL mediates programmed hepatocellular necrosis independently of RIPK3 during hepatitis. J Clin Invest 2016, 126 (11), 4346-4360.

Driehuis, E.; Kolders, S.; Spelier, S.; Lohmussaar, K.; Willems, S. M.; Devriese, L. A.; de Bree, R.; de Ruiter, E. J.; Korving, J.; Begthel, H.; van Es, J. H.; Geurts, V.; He, G. W.; van Jaarsveld, R. H.; Oka, R.; Muraro, M. J.; Vivie, J.; Zandvliet, M.; Hendrickx, A. P. A.; Iakobachvili, N.; Sridevi, P.; Kranenburg, O.; van Boxtel, R.; Kops, G.; Tuveson, D. A.; Peters, P. J.; van Oudenaarden, A.; Clevers, H., Oral Mucosal Organoids as a Potential Platform for Personalized Cancer Therapy. Cancer Discov 2019, 9 (7), 852-871.