侯尚国课题组主要从事高时空分辨生物动态光学显微成像及其生物学应用方向研究。研究方向包括：

1.多维动态光学显微成像技术开发；

2.病原体与宿主相互作用机制；

3.定量生物分子动态成像；

4.人工智能生物成像

近期代表性论:

Zhaoshuai Gao, Qian Li, Chunhai Fan*, Shangguo Hou*. Deciphering live-cell biomolecular dynamics with single-molecule fluorescence imaging. Science Bulletin. 2024. https://doi.org/10.1016/j.scib.2024.03.036. (Accepted).

Hao Sha, Haoyang Li, Yongbing Zhang*, Shangguo Hou*. Deep learning-enhanced single-molecule spectrum imaging. APL Photonics, 2023, 8 (9): 096102.

Xiufeng Zhang†, Haoyang Li†, Yue Ma†, Dongping Zhong*, and Shangguo Hou*. Study Liquid-liquid phase separation with optical microscopy: a methodology review. APL Bioengineering, 2023, 7(2): 021502. 

Shangguo Hou, Jack Exell, Kevin Welsher*. Real-time 3D Single Molecule Tracking. Nature Communications, 2020, 11, 3607

Shangguo Hou, Kevin Welsher*. An Adaptive Real-Time 3D Single Particle Tracking Method for Monitoring Viral First Contacts. Small, 2019, 15, 1903039

Shangguo Hou, Xiaoqi Lang, Kevin Welsher*. Robust real-time 3D single-particle tracking using a dynamically moving laser spot. Optics Letters, 2017, 42, 2390-2393.

Xiaochen Tan, Shangguo Hou, Anastasia Niver, Chen Zhang, Alexis Johnson, and Kevin D. Welsher* Active-feedback 3D single-molecule tracking using a fast-responding galvo scanning mirror. J. Phys. Chem. A., 2023. 217, 30, 6320-6328

Zhichao Liu, Ying Zhu, Liming Zhang, Weiping Jiang, Yawei Liu, Qiaowei Tang, Xiaoqing Cai, Jiang Li, Lihua Wang, Changlu Tao, Xianzhen Yin, Xiaowei Li, Shangguo Hou, Dawei Jiang, Kai Liu, Xin Zhou*, Hongjie Zhang*, Maili Liu*, Chunhai Fan*, Yang Tian*. Structural and functional imaging of brains. SCIENCE CHINA Chemistry. 2023, 66, 324–366

Siddharth Patel, N Ashwanikumar, Ema Robinson, Yan Xia, Cosmin Mihai, Joseph Griffith III, Shangguo Hou, Adam Esposito, Tatiana Ketova, Kevin Welsher, John Joyal, Orn Almarsson, Gaurav Sahay*. Naturally-occurring cholesterol analogues in lipid nanoparticles induce polymorphic shape and enhance intracellular delivery of mRNA. Nature Communications, 2020, 11, 983