课题组专注于生物与仿生体系的理论计算，主要研究方向包括但不限于：

染色质折叠：结合计算机模拟、生信分析和机器学习方法预测染色质高级结构及其对基因表达的调控。

生物相分离：通过理论计算揭示生物体系中相分离与相变的物理化学机制及其与生物学功能的关联。

仿生系统设计：基于生物体系的启发设计新型材料及人工智能算法。

近期代表性论:

Z. Shi, J. Xu, L. Niu, W Shen, S. Yan, Y. Tan, X. Quan, E. Cheung, K. Huang*, Y. Chen*, L. Li*, C. Hou*. Evolutionarily distinct and sperm-specific supersized chromatin loops are marked by Helitron transposons in Xenopus tropicalis. Cell Reports, 2023, 42(3):112151. (*co-corresponding author)

A. R. Shim, K. Huang*, V. Backman, I. Szleifer*. Chromatin as self-returning walks: From population to single cell and back. Biophysical Reports, 2022, 2(1), 100042.(*co-corresponding author)

J. Wang,  Y. Tao,  Y. Juan,  H. Zhou,  X. Zhao,  X. Cheng,  X. Wang,  X. Quan,  J. Li,  K. Huang*,  W. Wei*,  J. Zhao*. Hierarchical Assembly of Flexible Biopolymer Polyphosphate-Manganese into Nanosheets. Small, 2022, 18(41):e2203200.(*co-corresponding author)

S. Qin, K. Huang*, I. Szleifer*. Design of Multifunctional Nanopore Using Polyampholyte Brush with Composition Gradient. ACS Nano, 2021, 15(11):17678-17688. (*co-corresponding author)

K. Huang*, Y. Li,  A. R. Shim, R. K. A. Virk, V. Agrawal, A. Eshein, R. J. Nap, L. M. Almassalha, V. Backman*, I. Szleifer*. Physical and data structure of 3D genome. Science Advances, 2020, 6(2):eaay4055. (*co-corresponding author).

K. Huang, M. Tagliazucchi, S. H. Park, Y. Rabin, I. Szleifer. Nanocompartmentalization of the Nuclear Pore Lumen. Biophysical Journal, 2020, 118(1):219-231.

K. Huang, I. Szleifer. Design of Multifunctional Nanogate in Response to Multiple External Stimuli Using Amphiphilic Diblock Copolymer. Journal of the American Chemical Society, 2017, 139(18):6422-6430.

K. Huang*, I. Szlufarska. Effect of interfaces on the nearby Brownian motion. Nature Communications, 2015, 6(1):8558.(*co-corresponding author)