计算生物和疾病基因组学课题组主要通过开发和应用新的计算学方法，整合多种临床相关高通量组学大数据来解析人类衰老相关疾病的遗传和表观遗传的调控机理，以期识别潜在的可运用于临床实践的分子标记及治疗靶点。

近期代表性论:

Lin P^, Chen WY^, Long ZL, Yu JC, Yang JY, Xia Z, Wu QL, Min XY, Tang J, Cui Y,Liu FY, Wang C, Zheng J, Li W, Rich J N*, Li L*, Xie Q*. In vitro and in vivo CRISPR screens identify the ubiquitin E3 ligase RBBP6 as a targetable dependency of glioblastoma stem cells. Cell Discovery. 2024, 10, 32.

Chen H^, Wang ZY^, Gong LH, Wang QX, Chen WY, Wang J, Ma XL, Ding RF, Li X, Zou XD, Plass M, Lian C, Ni T, Wei GH, Li W*, Deng L*, Li L*. A distinct class of pan-cancer susceptibility genes revealed by alternative polyadenylation transcriptome-wide association study. Nature Communications. 2024, 15, 1729. 

Li L*, Ma XL, Cui Y, Rotival M, Chen WY, Zou XD, Ding RF, Qin YM, Wang QX, Quintana-Murci L, Li W*. Immune-response 3′UTR alternative polyadenylation quantitative trait loci contribute to variation in human complex traits and diseases. Nature Communications. 2023, 14, 8347.

Ding RF^, Wang QX^, Gong LH^, Zhang T, Zou XD, Xiong KW, Liao Q, Plass M, Li L*. scQTLbase: an integrated human single-cell eQTL database. Nucleic Acids Research. 2023, gkad781. 

Ding RF^, Zou XD^, Qin YM, Gong LH, Chen H, Ma XL, Guang SH, Chen Yu, Gao Wang*, Li L*. xQTLbiolinks: a comprehensive and scalable tool for integrative analysis of molecular QTLs. Briefings in Bioinformatics. 2023, bbad440.

Ma XL^, Cheng SM^, Ding RF, Zhao ZZ, Zou XD, Guang SH, Wang QX, Jing H, Chen Yu, Ting Ni, Li L*. ipaQTL-atlas: an atlas of intronic polyadenylation quantitative trait loci across human tissues. Nucleic Acids Research. 2022, 51(D1), D1046-D1052. 

Zou XD^, Ding RF^, Chen WY, Wang G, Cheng SM, Wang Q, Li W*, Li L*. Using population-scale transcriptomic and genomic data to map 3′UTR alternative polyadenylation quantitative trait loci. STAR Protocols. 2022, 3(3), 101566. 

Cui Y, Peng FL, Wang D, Li YM, Li JS, Li L*, Li W*. 3′aQTL-atlas: an atlas of 3′UTR alternative polyadenylation quantitative trait loci across human normal tissues. Nucleic Acids Research. 2022, 50(D1), D39-D45.

Li L, Huang K, Gao YP, Cui Y, Wang G, Nathan D, Li YM, Chen YE, Ji P, Peng F, William K, Wagner EJ, Li W. (2021) An atlas of alternative polyadenylation quantitative trait loci contributing to complex trait and disease heritability. Nature Genetics. 2021, 53: 994–1005.

Yang SW^, Li L^, Connelly JP, Porter SN, Kodali K, Gan HY, Park JM, Tacer KF, Tillman H, Peng JM, Shondra MP, Li W, Potts PR. (2020) A Cancer-Specific Ubiquitin Ligase Drives mRNA Alternative Polyadenylation by Ubiquitinating the mRNA 3′End Processing Complex. Molecular Cell. 77(6): 1206-1221.