本课题组的研究方向是DNA复制的表观遗传调控机制及其在肿瘤发生发展和细胞分化发育过程的作用。

Haizhen Long#; Liwei Zhang#; Mengjie Lv#; Zengqi wen#; Wenhao Zhang; Xiulan Chen; Peitao Zhang; Tongqing Li; Luyuan Chang; Caiwei Jin; Guozhao Wu; Xi Wang; Fuquan Yang; Jianfeng Pei; Ping Chen; Raphael Margueron; Haiteng Deng; Mingzhao Zhu*; Guohong Li*; H2A.Z facilitates licensing and activation of early replication origins, Nature, 2020, 577(7791):576-581

Li Huang#; Youwang Wang#; Haizhen Long#*; Haoqiang Zhu; Zengqi Wen; Liwei Zhang; Wenhao Zhang; Zhenqian Guo; Longge Wang; Fangyi Tang; Jie Hu; Keyan Bao; Ping Zhu*; Guohong Li*; Zheng Zhou*; Structural insight into H4K20 methylation on H2A.Z-nucleosome by SUV420H1, Molecular Cell, 2023, 83(16): 2884-2895

Yingying Zou#; Jiayao Pei#; Haizhen Long#; Liting Lan; Kejian Dong; Tingting Wang; Ming Li; Zhexuan Zhao; Lirun Zhu; Gangxuan Zhang; Xin Jin; Yang Wang; Zengqi Wen; Min Wei; Yunpeng Feng*; H4S47 O-GlcNAcylation regulates the activation of mammalian replication origins, Nature Structural & Molecular Biology, 2023 Jun;30(6):800-811.

Yan Wang#; Haizhen Long#; Juan yu#; Liping Dong#; Michel Wassef; Baowen Zhuo; Xia Li; Jicheng Zhao; Min Wang; Cuifang Liu; Zengqi Wen; Luyuan Chang; Ping Chen; Qian-fei Wang; Xueqing Xu; Raphael Margueron*; Guohong Li*; Histone variants H2A.Z and H3.3 coordinately regulate PRC2-dependent H3K27me3 deposition and gene expression regulation in mES cells, BMC Biology, 2018, 16(107).

Liuxin Shi; Li Huang; Haizhen Long; Aoqun Song; Zheng zhou*; Structural basis of nucleosomal H4K20 methylation by methyltransferase SET8, FASEB 2022 Jun;36(6)