肿瘤免疫，癌细胞DNA损伤与免疫应答，疫苗

本课题组致力于解析T细胞在肿瘤中浸润、存活的微环境支持条件以及在PD1抗体治疗条件下T细胞功能性衰竭的分子机制，并以此开发新型肿瘤免疫治疗策略、抗体药物和肿瘤疫苗。（获得2021年度海外优青资助）

Huang, Y.#, Lu, C.#, Wang, H., ... & Li, G. M. (2023). DNAJA2 deficiency activates cGAS-STING pathway via the induction of aberrant mitosis and chromosome instability. Nature Communications, 14(1):5246.

Cai, Y., Zhang, A., Lu, C.*. (2022). Precision intervention of cell type-specific targeting is required for future cancer immunotherapy. Medical Review, 2(6), 553-554.

Lu, C.#, Guan, J.#, Lu, S., Jin, Q., Rousseau, B., Lu, T., ... & Fu, Y. X. (2021). DNA sensing in mismatch repair-deficient tumor cells is essential for anti-tumor immunity. Cancer Cell, 39(1), 96-108. （This paper is elected as EACR’s Top 10 Cancer Research Publications in 2020; A highly cited paper in Web of Science.）

Guan, J.#, Lu, C.#, Jin, Q., Lu, H., Chen, X., Tian, L., ... & Li, G. M. (2021). MLH1 deficiency-triggered DNA hyperexcision by exonuclease 1 activates the cGAS-STING pathway. Cancer Cell, 39(1), 109-121. A highly cited paper in Web of Science.

Liu, L., Chen, J., Zhang, H., Ye, J., Moore, C., Lu, C., Fang, Y., Fu, Y. X., & Li, B. (2022). Concurrent delivery of immune checkpoint blockade modulates T cell dynamics to enhance neoantigen vaccine-generated antitumor immunity. Nature cancer, 3(4), 437–452.

Anli Zhang,Zhenhua Ren, Kuo-Fu Tseng, Xiaojuan Liu, Huiyu Li, Changzheng Lu, Yueqi Cai, John D. Minna, Yang-Xin Fu. (2021). Dual targeting of CTLA-4 and CD47 on Treg cells promotes immunity against solid tumors. Science Translational Medicine, 13(605), eabg8693.