课题组致力于于生物、医学、物理、化学、材料的交叉领域，针对生命科学与临床医学中的重要科学问题，开发前沿纳米生物技术、智能生物材料与器件，为疾病的诊断治疗和药物研发提供新思路。课题组聚焦于仿生生物材料的设计与制备，包括开发微流控芯片促进仿生材料的制备，使用化学共轭/基因编辑等方法实现仿生材料表面功能化，以及将仿生材料应用于癌症早期诊断、肿瘤特异性成像与靶向治疗、新型抗病毒药物的研发等领域。

Lang Rao, Shu-Kun Zhao, Churan Wen, Rui Tian, Lisen Lin, Bo Cai, Yue Sun, Fei Kang, Zhen Yang, Liangcan He, Jing Mu, Qian-Fang Meng, Guangyu Yao*, Ni Xie*, & Xiaoyuan Chen*. Activating Macrophage-Mediated Cancer Immunotherapy by Genetically Edited Nanoparticles. Advanced Materials, 2020, 32, 2004853. (Highlighted by MaterialsViews).

Lang Rao#, Lei Wu#, Zhida Liu#, Rui Tian, Guocan Yu, Zijian Zhou, Kuikun Yang, Hong-Gang Xiong, Anli Zhang, Guang-Tao Yu, Wenjing Sun, Han Xu, Jingya Guo, Andrew Li, Hongmin Chen*, Zhi-Jun Sun*, Yang-Xin Fu*, & Xiaoyuan Chen*. Hybrid cellular membrane nanovesicles amplify macrophage immune responses against cancer recurrence and metastasis. Nature Communications, 2020, 11, 4909. (Highly Cited Paper).

Lang Rao#, Shuai Xia#, Wei Xu#, Rui Tian, Guocan Yu, Chenjian Gu, Pan Pan, Qian-Fang Meng, Xia Cai, Di Qu, Lu Lu*, Youhua Xie*, Shibo Jiang*, & Xiaoyuan Chen*. Decoy nanoparticles protect against COVID-19 by concurrently adsorbing viruses and inflammatory cytokines. Proceedings of the National Academy of Sciences of the United States of America (PNAS), 2020, 117, 27141-27147. (Featured as Cover; Highlighted by The Scientist; ChemistryViews; Inverse; Infosurhoy; Scitech Daily).

Qian-Fang Meng#, Rui Tian#, Haiyi Long, Xianjia Wu, Jialin Lai, Olga Zharkova, Jiong-Wei Wang*, Xiaoyuan Chen*, & Lang Rao*. Capturing Cytokines with Advanced Materials: A Potential Strategy to Tackle COVID-19 Cytokine Storm. Advanced Materials, 2021, 33, 2100012.

Qian-Fang Meng#, Yuyue Zhao#, Chunbo Dong#, Yuanwei Pan, Lujie Liu, Jialin Lai, Zhida Liu, Guang-Tao Yu*, Xiaoyuan Chen*, & Lang Rao*. Genetically Programmable Fusion Cellular Vesicles for Cancer Immunotherapy. Angewandte Chemie International Edition, 2021, 60, 26320-26326.

Dan Wu#,*, Kuikun Yang#, Zhankui Zhang, Yunxuan Feng, Lang Rao*, Xiaoyuan Chen*, & Guocan Yu*. Metal-free bioorthogonal click chemistry in cancer theranostics. Chemical Society Reviews, 2022, 51, 1336-1376. (Highly Cited Paper). 

Chenchen Zhao, Yuanwei Pan, Guocan Yu*, Xing-Zhong Zhao, Xiaoyuan Chen*, & Lang Rao*. Vesicular Antibodies: Shedding Light on Antibody Therapeutics with Cell Membrane Nanotechnology. Advanced Materials, 2023, 35, 2207875.

Qian-Fang Meng#, Wanbo Tai#, Mingyao Tian#, Xinyu Zhuang#, Yuanwei Pan, Jialin Lai, Yangtao Xu, Zhiqiang Xu, Min Li, Guangyu Zhao, Guang-Tao Yu, Guocan Yu, Rongchang Chen, Ningyi Jin, Xiao Li*, Gong Cheng*, Xiaoyuan Chen*, & Lang Rao*. Inhalation delivery of dexamethasone with iSEND nanoparticles attenuates the COVID-19 cytokine storm in mice and non-human primates. Science Advances, 2023, 9, eadg3277. 

Dan Liu, Shuang Liang, Kongshuo Ma, Qian-Fang Meng, Xingang Li, Jian Wei, Mengli Zhou, Kaiqing Yun, Yuanwei Pan, Lang Rao*, Xiaoyuan Chen*, & Zhaohui Wang*. Tumor Microenvironment-Responsive Nanoparticles Amplifying STING Signaling Pathway for Cancer Immunotherapy. Advanced Materials, 2024, 36, 2304845.

Jialin Lai#, Qi Pan#, Guihao Chen#, Yu Liu, Cheng Chen, Yuanwei Pan, Lujie Liu, Binglin Zeng, Ling Yu, Yunsheng Xu, Jinyao Tang, Yuejin Yang*, & Lang Rao*. Triple Hybrid Cellular Nanovesicles Promote Cardiac Repair after Ischemic Reperfusion. ACS Nano, 2024, 18, 4443-4455. (Featured as Cover).