课题组主要研究方向为细胞内蛋白质稳态系统及精准药物智能设计。课题组以人群基因组及表型组为基础，利用多学科技术，包括计算生物学、分子生物学、细胞生物学、生物化学、生物物理学及多组学等手段，来揭示细胞、组织及个体在人群进化、环境应激及疾病衰老中调控蛋白质折叠及功能的分子机制，并进行精准药物的设计和研发。涉及疾病包括与蛋白质错误折叠相关的遗传病、罕见病、慢性阻塞性肺病、癌症及神经退行性疾病等。

Sun, S.*, Wang, C.*, Zhao, P., Kline, G., Grandjean, J., Jiang, X., Labaudiniere, R., Wiseman, R.L., Kelly, J.W., and Balch, W.E. (2023) Capturing the Conversion of the Pathogenic Alpha-1-Antitrypsin Fold by ATF6 Enhanced Proteostasis. (*contributed equally). Cell Chemical Biology 30(1): 22-42. · Highlighted by preview in Cell Chemical Biology.

Wang, C.*, Angles, F.*, & Balch, W.E. (2022) Triangulating variation in the population to define mechanisms for precision management of genetic disease. Structure. 30(8): 1190-1207. (*contributed equally). · Highlighted in Genetic Engineering & Biotechnology News, Cystic Fibrosis News Today, ScienceDaily, Scripps News&Views etc. 

Wang, C.*, Zhao, P.*, Sun, S.*, Teckman, J., & Balch, W.E. (2020) Leveraging Population Genomics for Individualized Correction of the Hallmarks of Alpha-1-Antitrypsin Deficiency (AATD). Chronic Obstr Pulm Dis. 7(3): 224-246. (*contributed equally). 

Wang, C. *, Scott, S.M.*, Sun, S., Zhao, P., Hutt, D.M., Shao, H., Gestwicki, J.E., & Balch, W.E.  (2020) : Individualized Management of Genetic Diversity in Niemann-Pick C1 through Modulation of the Hsp70 Chaperone System. Hum. Mol. Genet. 29(1):1-19. (*contributed equally). 

Wang, C., Scott, S.M., Subramanian, K., Loguercio, S., Zhao, P., Hutt, D.M., Farhat, N.Y., Porter, F.D., & Balch W.E. (2019) Quantitating the epigenetic transformation contributing to cholesterol homeostasis using Gaussian process. Nat. Commun. 10(1):5052. 

Wang, C., Balch, W.E. (2018) Bridging Genomics to Phenomics at Atomic Resolution Using Variation Spatial Profiling. Cell Reports. 24(8): 2013-2028. · Cover Story. · Highlighted in Trends in Genetics.