特聘研究员
细胞生物学
wangzixi@szbl.ac.cn
2023 至今 深圳湾实验室 特聘研究员
2016-2023 美国德州大学西南医学中心 博士后/教讲师
2013-2016 北京大学 博士后
2007-2013 北京大学 博士
2003-2007 河北大学 学士
课题组的研究包括脂肪肝和肝癌的治疗,肝脏再生机理和应用,以及肝脏相关的基础生物学问题。方向包括但不局限于:
1. 脂肪肝治疗新靶点的研发;
2. 肝硬化和肝癌的缓解和治疗;
3. 肝脏再生的分子基础;
4. 肝脏的区块化代谢机理;
5. 肝脏非实质细胞在脂肪肝发生和发展中的作用。
Wang, Z., Zhu, S., Jia, Y., Wang, Y., Kubota, N., Fujiwara, N., Gordillo, R., Lewis, C., Zhu, M., Sharma, T., Li, L., Zeng, Q., Lin, Y.H., Hsieh, M.H., Gopal, P., Wang, T., Hoare, M., Campbell, P., Hoshida, Y., Zhu, H. Positive selection of somatically mutated clones identifies adaptive pathways in metabolic liver disease. Cell. 186, 1968-1984, (2023) (Highlighted by Lan, et al. Signal Transduction and Targeted Therapy. 2023)
Wang, Z. and Zhu, H. Exploiting liver metabolism for tissue-specific cancer targeting. Nature Cancer. 4, 310-311, (2023) (News & Views)
Wang, Z., Chen, K., Jia, Y., Chuang, J-C., Sun, X., Lin, Y-H., Celen, C., Li, L., Huang, F., Liu, X., Castrillon, D.H., Wang, T., Zhu, H. Dual ARID1A/ARID1B loss leads to rapid carcinogenesis and disruptive redistribution of BAF complexes. Nature Cancer. 1, 909–922, (2020)
Wei, Y., Wang, Y. G., Jia, Y., Li, L., Yoon, J., Zhang, S., Wang, Z., Zhang, Y., Zhu, M., Sharma, T., Lin, Y. H., Hsieh, M. H., Albrecht, J. H., Le, P. T., Rosen, C. J., Wang, T., and Zhu, H. Liver homeostasis is maintained by midlobular zone 2 hepatocytes. Science. 371 (2021)
Huang, F., Huffman, K., Wang, Z., Wang, X., Li, K., Cai, F., Yang, C., Cai, L., Shih, T. S., Zacharias, L. G., Chung, A. S., Yang, Q., Chalishazar, M. D., Ireland, A. S., Stewart, C. A., Cargill, K. R., Girard, L., Liu, Y., Ni, M., Xu, J., Wu, X., Zhu, H., Drapkin, B. J., Byers, L. A., Oliver, T. G., Gazdar, A., Minna, J., and DeBerardinis, R. Guanosine triphosphate links MYC-dependent metabolic and ribosome programs in small cell lung cancer. JCI. 131, 1-18, (2021)
Wang, Z., Liu, Y., Huang, S., and Fang, M. TRAF6 interacts with and ubiquitinates PIK3CA to enhance PI3K activation. FEBS Letters. 592, 1882-1892, (2018) (Co-correspondence)
Wang, Z., Dang, T., Liu, T., Chen, S., Li, L., Huang, S., and Fang, M. NEDD4L Protein Catalyzes Ubiquitination of PIK3CA Protein and Regulates PI3K-AKT Signaling. JBC. 291, 17467-17477, (2016)