应用生物化学、病毒学、人工智能等多学科研究工具，系统研究病毒复制及免疫逃逸机理，为开发基因递送工具奠定基础，包括：（1）病毒包涵体的发生机制以及体外生化重构，在病毒复制以及同宿主互作中的作用，致病机理及分子诊断；（ 2）利用前沿生物物理手段，开发对病毒颗粒进行基于形状及内容的分选技术，研究病毒颗粒形状对侵染及致病性的影响，为提升疫苗有效率提供理论基础；（3）开发病毒复制小分子抑制剂以及高通量血清学技术。

C. Wu*, N. Wagner, A. B. Moyle, A. Feng, N. Sharma, S. H. Stubbs, C. Donahue, R. Davey, M. L. Gross, D. W. Leung*, and G. K. Amarasinghe*. Disruption of Ebola NP0VP35 Inclusion Body-like Structures Reduce Viral Infection. Journal of Molecular Biology, 2023, Aug 18; 168241.

C. Wu, A. S. Holehouse, D. W. Leung, G. K. Amarasinghe, R. E. Dutch. Liquid phase partitioning in virus replication: observations and opportunities. Annual Review of Virology, 2022. 9:23.

A. J. Qavi, C. Wu, M. Lloyd, M. M.-U. Zaman, J. Luan, C. Ballman, D. W. Leung, S. L. Crick, G. K. Amarasinghe, and C. W. Farnsworth. Plasmonic Fluor-Enhanced Antigen Arrays for High-Throughput, Serological Studies of SARS-CoV-2. ACS Infectious Diseases. 2022, 8, 8.

Q. Ming, D. P. Celias, C. Wu, A. R. Cole, S. Singh, C. Mason, S. Dong, T. H. Tran, G. K. Amarasinghe, B. Ruffell, V. C. Luca. LAG3 ectodomain structure reveals functional interfaces for ligand and antibody recognition. Nature Immunology, 2022. 1-11.

C. Wu, A.J. Qavi, A. Hachim, N. Kavian, A.R. Cole, A.B. Moyle, N.D. Wagner, J. Sweeney-Gibbons, H.W. Rohrs, M.L. Gross, J.S.M. Peiris, C.F. Basler, C.W. Farnsworth, S.A. Valkenburg, G.K. Amarasinghe, D.W. Leung. Characterization of SARS-CoV-2 N protein reveal multiple functional consequences of the C-terminal domain. iScience. 2021, 24, 201681

W. Wang#, C. Wu#, G.K. Amarasinghe, D.W. Leung. Ebola virus replication stands out. Trends in Microbiology. 2019, 27(7), 565-566. (# co-first author)

C. Wu, S.A. Wynne, N.E. Thomas, E.-M. Uhlemann, C.G. Tate, K. Henzler-Wildman. Identification of an alternating-access dynamics mutant of EmrE with impaired transport. Journal of Molecular Biology. 2019, 431(15), 2777-2789.

Z. Su#, C. Wu#, L. Shi, P. Luthra, G.D. Pintilie, B Johnson, J.R. Porter, P. Ge, M. Chen, G. Liu, T. E. Frederick, J.M. Binning, G.R. Bowman, Z. Zhou, C. Basler, M.L. Gross, D.W. Leung, W. Chiu, and G.K. Amarasinghe. Electron cryo-microscopy structure of Ebola nucleoprotein reveals a mechanism for nucleocapsid-like assembly. Cell. 2018, 172: 1-13 (# co-first author)

N. Thomas, C. Wu, E. Morrison, A. Robinson, J. Werner, K. Henzler-Wildman. The C-terminus of bacterial multidrug transporter EmrE couples drug binding to proton release. Journal of Biological Chemistry. 2018, 293(49): 19137.

Y. Zhou, C. Wu, L. Zhao, N. Huang. Exploring the early stages of the pH-induced conformational change of influenza hemagglutinin. Proteins. 2014, 82: 2412-2428.