免疫细胞如何感受和适应组织微环境(肠道免疫，肿瘤免疫，神经免疫)。

代谢（细胞代谢, 微生物代谢）如何影响免疫功能。

免疫系统如何与中枢神经系统互动。

Tang H, Wu L*. MAMPs: a devil tamed becomes an angel. Cell Host & Microbe. 2023. 31(9): 1422-1425

Wu L*, Hollinshead KER, Hao Y, Au C, Kroehling L, Ng C, Lin WY, Li D, Silva HM, Shin J, Lafaille JJ, Possemato R, Pacold ME, Papagiannakopoulos TY, Kimmelman AC, Satija R, Littman DR*. Niche-selective inhibition of pathogenic Th17 cells by targeting metabolic redundancy. Cell. 2020. 182: 641-654. 

Wu L#, Pan L#, Zhang C, Zhang M*. Large protein assemblies formed by multivalent interactions between cadherin23 and harmonin suggest a stable anchorage structure at the tip link of stereocilia. JBC. 2012. 287: 33460-33471 (# equal contribution)

Wu L#, Pan L#, Wei Z, Zhang M*. Structure of MyTH4-FERM domains in myosin VIIa tail bound to cargo. Science. 2011. 331:757-760 (# equal contribution)

Hall JA, Pokrovskii M, Kroehling L, Kim BR, Kim SY, Wu L, Lee JY, Littman DR*. Transcription factor RORα enforces stability of the Th17 cell effector program by binding to a Rorc cis-regulatory element. Immunity. 2022. 55(11): 2027-2043.

Xu H, Wu L, Nguyen H, Mesa KR, Raghavan V, Episkopou V, Littman DR*. Arkadia-SKI/SnoN signaling cascade differentially regulates TGF-β-induced iTreg and Th17 cell differentiation. JEM. 2021. 218 (11): e20210777.

Lee JY, Hall JA, Kroehling L, Wu L, Najar T, Nguyen HH, Lin WY, Yeung ST, Silver HM, Li D, Hine A, Loke P, Hudesman D, Martin JC, Kenigsberg E, Merad M, Khanna KM, Littman DR*. Serum amyloid A proteins induce pathogenic Th17 cells and promote inflammatory disease. Cell, 2020. 180: 79-91.

Hang S, Paik D, Devlin AS, Jamma T, Lu J, Ha S, Nelson BN, Kelly SP, Wu L, Zheng Y, Rastinejad F, Krout MR, Fischbach MA*, Littman DR*, Huh JR*. Bile acid metabolites control Th17 and Treg cell differentiation. Nature, 2019. 576, 143–148.

Ng C, Aichinger M, Nguyen T, Au C, Najar T, Wu L, Mesa KR, Liao W, Quivy JP, Hubert B, Almouzni G, Zuber J, Littman DR*. The histone chaperone CAF-1 cooperates with the DNA methyltransferases to maintain Cd4 silencing in cytotoxic T cells. Genes Dev. 2019. 33: 669-683.

Pan L, Yan J, Wu L, Zhang M*. Assembling stable hair cell tip link complex via multidentate interactions between harmonin and cadherin23. PNAS. 2009. 106: 5575-5580.