课题组主要研究方向为代谢重编程和蛋白翻译后修饰在恶性肿瘤发生发展中的调控机制，综合运用蛋白质多组学、代谢组学、肿瘤生物学、基因编辑工程和高通量筛选等技术手段，结合临床样本以及肿瘤类器官和动物模型，揭示癌症发生发展的关键代谢和信号通路，以挖掘癌症治疗新靶点和开发治疗新策略。

1. SLC25A1 and ACLY maintain cytosolic acetyl-CoA to regulate ferroptosis susceptibility via FSP1 acetylation. EMBO Journal. Li, W.#, Han, J.#, Huang, B. #, Xu, T. #, Wan, Y., Luo, D., Kong, W., Yu, Y., Zhang, L., Nian, Y. *, Chu, B. *, Yin, C. * 2025, https://doi.org/10.1038/s44318-025-00369-5

2. PTPN23-dependent activation of PI3KC2α is a therapeutic vulnerability of BRAF-mutant cancers. Journal of Experimental Medicine. 222(3): e20241147. He, Y.#, Li, W.#, Zhang, M. #, Wang, H., Lin, P., Yu, Y., Huang, B., Hao, M., He, J., Kong, W., Luo, D., Xu, T., Wang, J., Huang, Y., Zhao, Q., Liu, Y., Zhang, J., Nian, Y., Zhang, L., Zhu, B., Yin, C.* 2025/01. DOI:10.1084/jem.20241147

3. Palmitoylation-dependent regulation of GPX4 suppresses ferroptosis. Nature Communications. 16: 867. Huang, B.#, Wang, H.#, Liu, S.#, Hao, M.#, Luo, D., Zhou, Y., Huang, Y., Nian, Y., Zhang, L., Chu, B., Yin, C.* 2025/01. DOI:10.1038/s41467-025-56344-5

4. Pharmacological targeting of casein kinase 1δ suppresses oncogenic NRAS-driven melanoma. Nature Communications. 15, 10088. Wen, Y.#, Wang, H.#, Yang, X.#, Zhu, Y., Li, M., Ma, X., Huang, L., Wan, R., Zhang, C., Li, S., Jia, H., Guo, Q., Lu, X., Li, Z., Shen, X., Zhang, Q.*, Si, L.*, Yin, C.*, Liu, T*. 2024/11.

5. Gut microbial metabolism in ferroptosis and colorectal cancer. Trends in Cell Biology. 10(11), Cui, W.#, Hao, M.#, Yang, X.*, Yin, C.*, Chu, B*. 2024/08.

6. Tryptophan metabolism acts as a new anti-ferroptotic pathway to mediate tumor growth. Advanced Science. 10(6), 2204006. Liu, D.#, Liang, C.#, Huang, B.#, Zhuang, X., Cui, W., Yang, L., Yang, Y., Zhang, Y., Fu, X., Zhang, X., Du, L., Gu, W., Wang, X., Yin, C.*, Chai, R.*, Chu, B.* 2023/02.

7. Aberrant promoter methylation of Wnt inhibitory factor-1 gene is a potential target for treating psoriasis. Clinical Immunology. 252023, 0, 109294. Liu, L. #, Zhou, Y. #, Luo, D. #, Sun, X., Li, H., Lu, Y., Wang, J., Zhang, M., Lin, N., Yin, C.*, Li, X.*, 2023/01.

8. AMPK phosphorylates ZDHHC13 to increase MC1R activity and suppress melanomagenesis. Cancer Research. 83 (7): 1062–1073. Sun, Y.#, Li, X.#, Yin, C.#, Zhang, J., Liang, E., Wu, X., Ni, Y., Arbesman, J., Goding, C. R., Chen, S. 2023/01

9. Pharmacological targeting of STK19 inhibits oncogenic NRAS-driven melanomagenesis. Cell. 176(5), 1113-1127. Yin, C.#, Zhu, B.#, Zhang, T.#, Liu, T.#, Chen, S., Liu, Y., Li, X., Miao, X., Li, S., Mi, X., Zhang, J., Li, L., Wei, G., Xu, Z., Gao, X., Huang, C., Wei, Z., Goding, C. R., Wang, P.*, Deng, X.*, Cui, R.* 2019/02

10. Palmitoylation-dependent activation of MC1R prevents melanomagenesis. Nature. 549(7672), 399-403. Chen, S.#, Zhu, B.#, Yin, C.#, Liu, W., Han, C., Chen, B., Liu, T., Li, X., Chen, X., Li, C., Hu, L., Zhou, J., Xu, Z., Gao, X., Wu, X., Goding, C. R., Cui, R. 2017/09