导师风采
Tutor's Demeanor
教育培养 招生工作 导师风采
张浩岳

特聘研究员

研究领域

生物化学与分子生物学

个人邮箱

zhang_adam@szbl.ac.cn

教育与工作经历

2021 至今 深圳湾实验室 特聘研究员

2016-2021 美国费城儿童医院 博士后

2011-2016 美国马里兰大学帕克分校 博士

2007-2011 同济大学 学士

研究方向

表观遗传学,基因组学,3D基因组学,转录调控与疾病,有丝分裂,衰老


代表论文

Preprints

1. Aboreden, N.,…Zhang H* & Blobel, G*. Cis-regulatory chromatin contacts form de novo in the absence of loop extrusion. BioRxiv, 2025.01. 12.632634


Primary research publications

1. Li T., Wang G.,…Zhang H*. & Yang J*. Estrogen receptor 1 signaling in hepatic stellate cells designates resistance to liver fibrosis. Cell Discovery, (2025). https://doi.org/10.1038/s41421-025-00783-3

2. Zhao H., Shu L.,…Zhang H*. Extensive mutual influences of SMC complexes shape 3D genome folding. Nature, (2025). https://doi.org/10.1038/s41586-025-08638-3

3. Zhao H.,…Zhang H*. Genome folding principles uncovered in condensin-deficient mitotic chromosomes. Nature Genetics, 56(6):1213-1224 (2024).

4. Zhang H*. et al. CTCF and transcription influence chromatin structure re-configuration after mitosis. Nat Commun 12, 5157 (2021).

5. Zhang H. et al. Chromatin structure dynamics during the mitosis-to-G1 phase transition. Nature 576, 158-162 (2019).

6. Zhang H. et al. Loss of H3K9me3 Correlates with ATM Activation and Histone H2AX Phosphorylation Deficiencies in Hutchinson-Gilford Progeria Syndrome. PLoS One 11, e0167454 (2016).

7. Zhang H., Xiong, Z.M. & Cao, K. Mechanisms controlling the smooth muscle cell death in progeria via down-regulation of poly(ADP-ribose) polymerase 1. Proc Natl Acad Sci USA 111, E2261-70 (2014)


Review publications

1. Zhang H*. & Blobel, G.A. Genome folding dynamics during the M-to-G1-phase transition. Curr Opin Genet Dev 80, 102036 (2023).

2. Zhang H and Cao K. Mechanisms of Genome Instability in Hutchinson-Gilford Progeria. Frontiers in Biology, DOI 10.1007/s11515-016-1435-x (2016)

3. Zhang H., Kieckhaefer, J.E. & Cao, K. Mouse models of laminopathies. Aging Cell 12, 2-10 (2013).


Other publications

1. Aboreden Nicholas,…, Zhang Haoyue, Hansen Anders, Blobel Gerd*. LDB1 establishes multi-enhancer networks to regulate gene expression. Molecular Cell (2025).

2. Lam Jessica,…, Zhang Haoyue, Blobel Gerd*. YY1-controlled regulatory connectivity and transcription are influenced by the cell cycle. Nature Genetics 56, 1938-1952, doi:10.1038/s41588-024-01871-y (2024).

3. Luan J, Vermunt MW, Syrett CM, Cote A, Tome JM, Zhang H, et al. CTCF blocks antisense transcription initiation at divergent promoters. Nature structural & molecular biology. 2022;29(11):1136-44.

4. Linares-Saldana R, Kim W, Bolar NA, Zhang H, Koch-Bojalad BA, Yoon S, et al. BRD4 orchestrates genome folding to promote neural crest differentiation. Nat Genet. 2021;53(10):1480-92.

5. Luan J, Xiang G, Gomez-Garcia PA, Tome JM, Zhang Z, Vermunt MW, Zhang H, et al. Distinct properties and functions of CTCF revealed by a rapidly inducible degron system. Cell reports. 2021;34(8):108783.

6. Zhang D, Huang P, Sharma M, Keller CA, Giardine B, Zhang H, et al. Alteration of genome folding via contact domain boundary insertion. Nat Genet. 2020;52(10):1076-87.

7. Wang K, Wu D, Zhang H, Das A, Basu M, Malin J, et al. Comprehensive map of age-associated splicing changes across human tissues and their contributions to age-associated diseases. Sci Rep. 2018;8(1):10929.

8. Atchison L, Zhang H, Cao K, and Truskey GA. A Tissue Engineered Blood Vessel Model of Hutchinson-Gilford Progeria Syndrome Using Human iPSC-derived Smooth Muscle Cells. Sci Rep. 2017;7(1):8168.

9. Tariq Z, Zhang H, Chia-Liu A, Shen Y, Gete Y, Xiong ZM, et al. Lamin A and microtubules collaborate to maintain nuclear morphology. Nucleus (Austin, Tex). 2017;8(4):433-46.

10. Wu D, Yates PA, Zhang H, and Cao K. Comparing lamin proteins post-translational relative stability using a 2A peptide-based system reveals elevated resistance of progerin to cellular degradation. Nucleus (Austin, Tex). 2016;7(6):585-96.

11. Xiong ZM, Choi JY, Wang K, Zhang H, Tariq Z, Wu D, et al. Methylene blue alleviates nuclear and mitochondrial abnormalities in progeria. Aging cell. 2015.

12. McCord RP, Nazario-Toole A, Zhang H, Chines PS, Zhan Y, Erdos MR, et al. Correlated alterations in genome organization, histone methylation, and DNA-lamin A/C interactions in Hutchinson-Gilford progeria syndrome. Genome research. 2013;23(2):260-9.