我们运用果蝇、小鼠、和人体诱导干细胞分化而来的神经元作为模型研究神经疾病的分子机理。我们重点关注应激颗粒、线粒体等细胞器在渐冻人症，额颞叶认知障碍症，以及一些遗传性神经发育疾病中的作用。

Xiong Y, Ma C, Li Q, Zhang W, Zhao H, Ren P, Zhang K*, Lei X*. (2023) Melatonin ameliorates simulated-microgravity-induced mitochondrial dysfunction and lipid metabolism dysregulation in hepatocytes. FASEB Journal. 37(9):e23132.

Sahana TG#, Chase K, Liu F, Rossoll W, Lloyd TE, and Zhang K*. (2023) c-Jun N-terminal Kinase Promotes Stress Granule Assembly and Neurodegeneration in C9orf72-mediated ALS and FTD. Journal of Neuroscience. 43(17):3186-3197. 

Gao J, Mewborne QT, Girdhar A, Sheth U, Coyne AN, Punathil R, Kang BG, Dasovich M, Veire A, Liu S, Shi Z, Dafinca R, Fouquerel E, Talbot K, Kam T-I, Zhang Y-J, Dickson D, Petrucelli L, Guo L, Dawson TM, Dawson VL, Leung AKL, Lloyd TE, Gendron TF, Rothstein JD, and Zhang K*. Poly(ADP-ribose) promotes toxicity of C9ORF72 arginine-rich dipeptide repeat proteins. Science Translational Medicine. 2022, In print

Maxwell B, Gwon Y, Mishra A, Peng J, Nakamura H, Zhang K, Kim HJ and Taylor JP. Ubiquitination is essential for recovery of cellular activities following heat shock. Science. 2021;372(6549):eabc3593; DOI: 10.1126/science.abc3593

Tang X, Toro A, T G Sahana, Gao J, Chalk J, Oskarsson B, Zhang K*. Divergence, Convergence, and Therapeutic Implications: A Cell Biology Perspective of C9ORF72-ALS/FTD. Review. Molecular Neurodegeneration. 2020;15(1):34.

Zhang K, Daigle JG, Cunningham KM, Coyne AC, Ruan K, Grima JC, Bowen KE, Wadhwa H, Yang P, Rigo F, Taylor JP, Gitler AD, Rothstein JD, Lloyd TE. Stress granule assembly disrupts nucleocytoplasmic transport, Cell. 2018;173(4):958-971.e17.

Zhang K*, Rothstein JD*. Neurodegenerative disease: Two-for-one on potential therapies. Preview. Nature. 2017;544(7650):302-303. 

Zhang K, Donnelly CJ*, Haeusler AR, Grima JC, Machamer JB, Steinwald P, Daley EL, Miller SJ, Cunningham KM, Vidensky S, Gupta S, Thomas MA, Hong I, Chiu SL, Huganir RL, Ostrow LW, Matunis MJ, Wang J, Sattler R, Lloyd TE, Rothstein JD. (2015) The C9orf72 repeat expansion disrupts nucleocytoplasmic transport. Nature. 525(7567):56-61.

Zhang K, Li Z, Jaiswal M, Bayat V, Xiong B, Sandoval H, Charng WL, David G, Haueter C, Yamamoto S, Graham BH, Bellen HJ. (2013) The C8ORF38 homologue Sicily is a cytosolic chaperone for a mitochondrial complex I subunit. J Cell Biol. 200(6):807-20.