1.探索病原体感染引起的程序性细胞死亡，包括凋亡、焦亡、程序性坏死及其潘亡活化的调控机制

2.探索病原体感染/非外来物入侵引起的炎症小体活化的调控机制

3.探索呼吸道病毒感染过程中炎症反应信号的增强机制

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Zheng M., Karki R., Vogel P., & Kanneganti T.D., Caspase-6 is a key regulator of innate immunity, inflammasome activation, and host defense. Cell. 2020 Apr 30;181(3):674-687.

Zheng M., Williams E.P., Malireddi R.K.S., Karki R., et al., (2020). Impaired NLRP3 inflammasome activation/pyroptosis leads to robust inflammatory cell death via caspase-8/RIPK3 during coronavirus infection. Journal of Biological Chemistry. 2020 Oct 9;295(41):14040-14052.

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