本课题组聚焦于肿瘤微环境中T细胞功能调控的营养代谢与表观遗传交叉机制， 我们将以小鼠为模型，结合蛋白组学、代谢组学、表观组学以及遗传学等多组学手段，系统解析肿瘤内T细胞营养感知的分子机制，并围绕以下两个核心科学问题展开研究：

（1）在肿瘤微环境中，T细胞如何选择性感知并响应不同类型的营养物质以调控其表观遗传图谱及功能？

（2）在系统代谢紊乱条件下，T细胞如何整合并协调局部与全身性代谢信号，以维持其抗肿瘤能力？

索尔克生物研究院创新博士后基金 （2019-2020）

Cancer research institute博士后基金 （2020-2023）

AAI 口头报告奖 （2024）

AAI 优秀墙报奖 （2025）

1.Shixin Ma; Michael S. Dahabieh; Thomas H. Mann; Steven Zhao; Bryan McDonald; Won-Suk Song; H. Kay Chung; Yagmur Farsakoglu; Lizmarie Garcia-Rivera; Filipe Araujo Hoffmann; Shihao Xu; Victor Y. Du; Dan Chen; Jesse Furgiuele; Michael A. LaPorta; Emily Jacobs; Lisa M. DeCamp; Brandon M. Oswald; Ryan D. Sheldon; Abigail E. Ellis; Longwei Liu; Peixiang He; Yingxiao Wang; Cholsoon Jang; Russell G. Jones; Susan M. Kaech ; Nutrient-driven histone code determines exhausted CD8 + T cell fates, Science, 2025, 387(6734)

2. Heleen H. Van Acker; Shixin Ma; Tommaso Scolaro; Susan M. Kaech; Massimiliano Mazzone; How metabolism bridles cytotoxic CD8+ T cells through epigenetic modifications, Trends in Immunology, 2021, 42(5): 401-41

3. Ma, Shixin; Wan, Xiaoling; Deng, Zihou; Shi, Lei; Hao, Congfang; Zhou, Zhenyuan; Zhou, Chun; Fang, Yiyuan; Liu, Jinghua; Yang, Jing; Chen, Xia; Li, Tiantian; Zang, Aiping; Yin, Shigang; Li, Bin; Plumas, Joel; Chaperot, Laurence; Zhang, Xiaoming; Xu, Guoliang; Jiang, Lubin; Shen, Nan; Xiong, Sidong; Gao, Xiaoming; Zhang, Yan; Xiao, Hui ; Epigenetic regulator CXXC5 recruits DNA demethylase Tet2 to regulate TLR7/9-elicited IFN response in pDCs, JOURNAL OF EXPERIMENTAL MEDICINE, 2017, 214(5): 1471-1491

4. Siva Karthik Varanasi; Shixin Ma; Susan M.Kaech ; T Cell Metabolism in a State of Flux,Immunity, 2019, 51(5): 783-785

5. Deng, Zihou; Ma, Shixin; Zhou, Hao; Zang, Aiping; Fang, Yiyuan; Li, Tiantian; Shi, Huanjing; Liu, Mei; Du, Min; Taylor, Patricia R.; Zhu, Helen He; Chen, Jiangye; Meng, Guangxun; Li, Fubin; Chen, Changbin; Zhang, Yan; Jia, Xin-Ming; Lin, Xin; Zhang, Xiaoming; Pearlman, Eric; Li, Xiaoxia; Feng, Gen-Sheng; Xiao, Hui ; Tyrosine phosphatase SHP-2 mediates C-type lectin receptor-induced activation of the kinase Syk and anti-fungal TH17 responses, NATURE IMMUNOLOGY, 2015, 16(6): 642-652

6. Irem Kaymak; McLane J. Watson; Brandon M. Oswald; Shixin Ma; Benjamin K. Johnson; Lisa M. DeCamp; Batsirai M. Mabvakure; Katarzyna M. Luda; Eric H. Ma; Kin Lau; Zhen Fu; Brejnev Muhire; Susan M. Kitchen-Goosen; Alexandra Vander Ark; Michael S. Dahabieh; Bozena Samborska; Matthew Vos; Hui Shen; Zi Peng Fan; Thomas P. Roddy; Gillian A. Kingsbury; Cristovão M. Sousa; Connie M. Krawczyk; Kelsey S. Williams; Ryan D. Sheldon; Susan M. Kaech; Dominic G. Roy; Russell G. Jones ; ACLY andACSS2 link nutrient-dependent chromatin accessibility to CD8 T cell effector responses, Journal of Experimental Medicine, 2024, 221(9)

7. Bryan McDonald; Brent Y. Chick; Nasiha S. Ahmed; Mannix Burns; Shixin Ma; Eduardo Casillas; Dan Chen; Thomas H. Mann; Carolyn O’Connor; Nasun Hah; Diana C. Hargreaves; Susan M. Kaech; Canonical BAF complex activity shapesthe enhancer landscape that licenses CD8(+) T cell effector and memory fates, Immunity, 2023, 56(6): 1303-1319.E5

8. Dan Chen; Siva Karthik Varanasi; Toshiro Hara; Kacie Traina; Ming Sun; Bryan McDonald; Yagmur Farsakoglu; Josh Clanton; Shihao Xu; Lizmarie Garcia-Rivera; Thomas H. Mann; Victor Du; H. Kay Chung; Ziyan Xu; Victoria Tripple; Eduardo Casillas; Shixin Ma; Carolyn O’Connor; Qiyuan Yang; Ye Zheng; Tony Hunter; Greg Lemke; Susan M. Kaech ; CTLA-4 blockade induces a microglia-Th1 cell partnership that stimulates microglia phagocytosis and anti-tumor function in glioblastoma, Immunity, 2023, 56(9): 2086-2104.E8

9. Lei Shi; Xia Chen; Aiping Zang; Tiantian Li; Yanxiang Hu; Shixin Ma; Mengdie Lü; Huiyong Yin; Haikun Wang; Xiaoming Zhang; Bei Zhang; Qibin Leng; Jinbo Yang; Hui Xiao; TSC1/mTOR- controlled metabolic–epigenetic cross talk underpins DC control of CD8+ T-cell homeostasis, PLOS Biology, 2019, 17(8)

10. Chun Zhou; Xia Chen; Rosa Planells-Cases; Jiachen Chu; Li Wang; Limin Cao; Zhihong Li; Karen I. López-Cayuqueo; Yadong Xie; Shiwei Ye; Xiang Wang; Florian Ullrich; Shixin Ma; Yiyuan Fang; Xiaoming Zhang; Zhikang Qian; Xiaozheng Liang; Shi-Qing Cai; Zhengfan Jiang; Dongming Zhou; Qibin Leng; Tsan S. Xiao; Ke Lan; Jinbo Yang; Huabin Li; Chao Peng; Zhaozhu Qiu; Thomas J. Jentsch; Hui Xiao ; Transfer of cGAMP into Bystander Cells via LRRC8 Volume-Regulated Anion Channels Augments STING-Mediated Interferon Responses and Anti-viral Immunity, Immunity, 2020, 52(5): 767-781.e6

11. Cao L, Wang L, Li Z, Wei X, Ding J, Zhou C, Chen X, Huang Z, Shao Z, Shen J,Lou H, Zhao K, Huang Y, Yang Y, Liu H, Sun Y, Niu J, Jiang S, Lu R, Tang L, ZhangX, Zhang H, Xiao Y, Chen J, Ma S, Gao C, Meng G, Liu L, Qiu Z, Wang H, Deng L,Ye Y, Jia XM, Li H, Xiao H. 2025. Radiotherapy enhances anticancer CD8 T cell responses by cGAMP transfer through LRRC8A/C volume-regulated anion channels. Sci Immunol 10: eadn1630