Immune receptors play a crucial role in human immunity and are important therapeutic targets for tumor immunotherapy and autoimmune diseases. Our group mainly uses diverse techniques such as biochemistry, immunology, cell biology, and structural biology to explore the working principles of important immune receptors. We will combine biochemical and structural analysis to design and screen antibodies that target immune receptors, aiming to precisely regulate immune cell functions. Moreover, we will conduct preclinical studies on these antibodies, primarily applying them in key areas such as tumors and infectious diseases. In addition to these goals, we will design and improve new immune receptor ligands based on the working mechanism of immune receptors. We hope to apply these new immune receptor ligands in immunotherapy, thereby promoting the development of a new generation of immunotherapy treatments. Our main research directions are as follows:

1. Molecular mechanisms of key immune receptors

2. Development of specific antibodies against key immune receptors

3. Design of new immune receptor ligands

Dr. Su (suqiang@smart.org.cn) has extensive experience in the structural biology of immune receptors. To date, he has published 13 articles in prestigious journals, including 2 papers in Nature (2025, 2024), 2 in Science (2022, 2018), 1 in Cell Discovery (2026), and 4 in Nature Communications (2026a, 2026b, 2021, 2018) as first or corresponding author. Additionally, he has co-authored 4 papers in journals such as Cell Research and PNAS. His landmark achievements include the structural determination of the complete B cell receptor (2022, Science), the complete γδ T cell receptor (2024, Nature), and the complete Fc receptor (2025, Nature).

2022 Outstanding Postdoctoral Fellow, Westlake University

2019 Outstanding Doctoral Student, Center for Advanced Studies, Tsinghua University

Served as an independent reviewer for international renowned journals Signal Transduction and Targeted Therapy (IF: 38.1), Allergy (IF: 12.4).

^#corresponding author

1. Weizhi Xin, Bangdong Huang, Weijie Gao, Wenjia Zhang, Yundi Hu, Yuehua Liu, Enyuan Liang, Jin Chen, Yigong Shi, Qiang Su^# & Qiang Zhou^#. (2026). Phosphoantigen-driven dissociation of butyrophilin oligomers activates γδ T cells. Cell Discovery. 12(1):59.

2. Tingshuai Ma, Ziyan Chen, Enyuan Liang^#, Xiufei Tang, Ximin Chi, Quanchang Gu^#, Qiang Su^#. (2026). Structural insights into ligand recognition and activation of the human oxoglutarate receptor OXGR1. Nature Communications. (Online ahead of print).

3. Mengying Chen, Zhifei Wang, Yan Shi, Gaoxingyu Huang, Tiago D C Morais, Akhilraj R Pillai, Yan Wang, Moushumi Afroza Mou, Dan Jing, Rongyan Fan, Fayang Zhou, Zhangsuo Liu, Qiang Su^#, Yong Yu^#, Yigong Shi^#. (2026). Structural basis of lipid-dependent allosteric gating mechanisms for PC1-PC2 ion channel. Nature Communications. (Online ahead of print).

4. Mengying Chen, Qiang Su^#, and Yigong Shi^#. (2025). Molecular mechanisms of IgE-mediated FcεRI activation. Nature. 637(8045):453-460.

5. Weizhi Xin, Bangdong Huang, Ximin Chi, Yuehua Liu, Mengjiao Xu, Yuanyuan Zhang, Xu Li, Qiang Su^#, and Qiang Zhou^#. (2024). Structures of human γδ T cell receptor–CD3 complex. Nature. 630(8015): 222-229.

6. Qiang Su^#, Mengying Chen, Yan Shi, Xiaofeng Zhang, Gaoxingyu Huang, Bangdong Huang, Dongwei Liu, Zhangsuo Liu, and Yigong Shi^#. (2022). Cryo-EM structure of the human IgM B cell receptor. Science. 337(6608):875-880.

7. Qiang Su^#, Mengying Chen, Yan Wang, Bin Li, Dan Jing, Xiechao Zhan, Yong Yu, and Yigong Shi^#. (2021). Structural basis for Ca²⁺ activation of the heteromeric PKD1L3/PKD2L1 channel. Nature Communications. 12(1):4871.

8. Qiang Su, Feizhuo Hu, Xiaofei Ge, Jianlin Lei, Shengqiang Yu, Tingliang Wang, Qiang Zhou, Changlin Mei and Yigong Shi^#. (2018). Structure of the human PKD1-PKD2 complex. Science. 361(6406):eaat9819.

9. Qiang Su, Feizhuo Hu, Yuxia Liu, Xiaofei Ge, Changlin Mei, Shengqiang Yu, Aiwen Shen, Qiang Zhou, Chuangye Yan, Jianlin Lei, Yanqing Zhang^#, Xiaodong Liu^# and Tingliang Wang^#. (2018). Cryo-EM structure of the polycystic kidney disease-like channel PKD2L1. Nature Communications. 9(1):1192.

 https://smart.org.cn/career/research-lab/341.html