i-BRAIN, the Institute for Brain Research, Advanced Interfaces and Neurotechnologies, is a highly-interdisciplinary research institute focused on developing transformative brain-computer interfaces (BCIs) that blur the distinction between electronics and the brain. Founded by world-renowned scientist Prof. Charles Lieber, i-BRAIN will enable groundbreaking research to understand the brain and brain diseases as well as breakthrough technologies for treatment of neurological and neurodegenerative diseases for the near-term but also enable future advances and treatments that today may be considered the realm of science fiction. Additionally, i-BRAIN will instill a positive and highly interdisciplinary culture in the training of young scientists, engineers and doctors such that they are prepared to lead the development of science and engineering as well as the translation of ideas into commercial technologies that benefit present and future generations.