科研队伍
Principal Investigators
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潘孝敬

特聘研究员

研究领域

结构生物学

个人邮箱

panxj(at)smart.org.cn

研究方向

主要运用结构生物学、生物化学及生理学等多学科手段,致力于探究重大疾病相关膜蛋白的工作机理与药物作用机制。当前重点关注与全身代谢性疾病、神经发育及调控相关的膜蛋白研究方向。

研究成果

潘孝敬,深圳医学科学院特聘研究员,国家自然科学基金优秀青年基金获得者。自博士后工作开始,先后获得中国博士后基金会的“博新计划”,国自然的青年基金,面上项目,北京市科委的“科技新星”等经费支持。潘孝敬在国际顶级学术期刊Science上以第一作者(含共一)发表文章5篇,以共通讯作者在PNASNature Communications等杂志发表文章8篇。


教育与工作经历

2023 - 至今深圳医学科学院 特聘研究员

2019 - 2023清华大学 生命科学院 副研究员

2016 - 2019清华大学 医学院 博士后

2011 - 2016清华大学 医学院 博士

2007 - 2011中国科学技术大学 生命科学院 学士

奖项荣誉

2021     中国博士后基金会优秀创新成果

2019     北京市科委评选“科技新星”

2019     清华大学结构生物学高精尖中心卓越青年科学家

2018     清华大学优秀博士后

2016     中国博士后基金会“博新计划”

2016     北京市优秀毕业生

2013     教育部博士生国家奖学金

2012     教育部硕士生国家奖学金

2012     教育部第十七届博士生学术新人奖

2012     清华大学“蒋南翔”奖学金

2011     安徽省优秀毕业生,中国科学技术大学优秀毕业生


代表论文

*代表共同第一作者,#代表共同通讯作者。


1.Huang, J., Pan, X.#,  Yan, N#. 2024. Structural biology and molecular pharmacology of voltage-gated ion channels. Nature Reviews Molecular Cell Biology, 1-22.


2.Shen, Z. *, Xu, L. *, Wu, T. *, Wang, H. *, Wang, Q., Ge, X., Huang, G., Pan, X#. 2024. Structural basis for urate recognition and apigenin inhibition of human GLUT9. Nature Communications, 15(1), 5039.


3.Wu, Q.*, Huang, J.*#, Fan, X.*#, Wang, K.*, Jin, X., Huang, G., Li, J., Pan, X.and Yan, N.#, 2023. Structural mapping of Nav1. 7 antagonists. Nature Communications14(1), p.3224.


4.Huang, G.*, Wu, Q.*, Li, Z.*, Jin, X.*, Huang, X., Wu, T., Pan, X.#and Yan, N.#, 2022. Unwinding and spiral sliding of S4 and domain rotation of VSD during the electromechanical coupling in Nav1. 7. Proceedings of the National Academy of Sciences119(33), p.e2209164119.


5.Huang, X.*, Jin, X.*, Huang, G., Huang, J., Wu, T., Li, Z., Chen, J., Kong, F., Pan, X.#and Yan, N.#, 2022. Structural basis for high-voltage activation and subtype-specific inhibition of human Nav1. 8. Proceedings of the National Academy of Sciences119(30), p.e2208211119.


6.Pan, X.*#, Li, Z.*, Jin, X.*, Zhao, Y.*, Huang, G.*, Huang, X., Shen, Z., Cao, Y., Dong, M., Lei, J. and Yan, N.#, 2021. Comparative structural analysis of human Nav1. 1 and Nav1. 5 reveals mutational hotspots for sodium channelopathies. Proceedings of the National Academy of Sciences118(11), p.e2100066118.


7.Li, Z., Jin, X., Wu, T., Zhao, X., Wang, W., Lei, J., Pan, X.#and Yan, N.#, 2021. Structure of human Nav1. 5 reveals the fast inactivation-related segments as a mutational hotspot for the long QT syndrome. Proceedings of the National Academy of Sciences118(11), p.e2100069118.


8.Shen, H.#, Yan, N.#and Pan, X.#, 2021. Structural determination of human Nav1. 4 and Nav1. 7 using single particle cryo-electron microscopy. Methods in Enzymology (Vol. 653, pp. 103-120). Academic Press.


9.Chi, X.*, Jin, X.*, Chen, Y.*, Lu, X., Tu, X., Li, X., Zhang, Y., Lei, J., Huang, J., Huang, Z.#, Zhou, Q.#, and Pan, X.#, 2020. Structural insights into the gating mechanism of human SLC26A9 mediated by its C-terminal sequence. Cell Discovery6(1), p.55.


10.Pan, X.*, Li, Z.*, Huang, X.*, Huang, G.*, Gao, S., Shen, H., Liu, L., Lei, J. and Yan, N., 2019. Molecular basis for pore blockade of human Na+ channel Nav1. 2 by the μ-conotoxin KIIIA. Science363(6433), pp.1309-1313.


11.Pan, X.*, Li, Z.*, Zhou, Q.*, Shen, H.*, Wu, K.*, Huang, X., Chen, J., Zhang, J., Zhu, X., Lei, J. and Xiong, W., Gong, H., Xiao, B., and Yan, N., 2018. Structure of the human voltage-gated sodium channel Nav1. 4 in complex with β1. Science.362(6412), p.eaau2486.


12.Shen, H.*, Li, Z.*, Jiang, Y.*Pan, X.*, Wu, J., Cristofori-Armstrong, B., Smith, J.J., Chin, Y.K., Lei, J., Zhou, Q.#and King, G.F.#, and Yan, N.#, 2018. Structural basis for the modulation of voltage-gated sodium channels by animal toxins. Science362(6412), p.eaau2596.


13.Shen, H.*, Zhou, Q.*Pan, X.*, Li, Z.*, Wu, J. and Yan, N., 2017. Structure of a eukaryotic voltage-gated sodium channel at near-atomic resolution. Science355(6328), p.eaal4326.


14.Deng, D.*, Yan, C.*Pan, X.*, Mahfouz, M., Wang, J., Zhu, J.K., Shi, Y.#and Yan, N.#, 2012. Structural basis for sequence-specific recognition of DNA by TAL effectors. Science335(6069), pp.720-723.