丹扬教授长期致力于神经科学研究，在视觉感知、注意、睡眠的神经机制领域做出了重要贡献。近年来，她运用多种生理学和分子生物学前沿技术，全面解析调控睡眠的神经环路，开启了睡眠研究领域的新篇章。

目前，丹扬教授团队以小鼠和非人灵长类为模型，采用脑电/肌电记录、在体双光子成像、在体电生理记录、神经示踪、光遗传/化学遗传学操作、高通量测序、分子遗传操作、细胞和分子生物学等多种实验手段开展研究，致力于解决意识的神经基础以及有关睡眠的两个基本问题：为什么睡眠？以及如何调控睡眠？

2008年 霍华德·休斯医学研究所（Howard Hughes Medical Institute，HHMI）研究员

2018年 美国国家科学院院士

2023年 爱德华·M·斯科尔尼克神经科学奖

2024年 彼得·西伯格综合神经科学奖

2025年 美国艺术与科学院院士

1. Silverman D, Chen C, Chang S, Bui L, Zhang Y, Raghavan R, Jiang A, Le A, Darmohray D, Sima J, Ding X, Li B, Ma C, Dan Y. Activation of locus coeruleus noradrenergic neurons rapidly drives homeostatic sleep pressure. Science Advances. 11: eadq0651. PMID 39823324 DOI: 10.1126/sciadv.adq0651

2. Ma C, Li B, Silverman D, Ding X, Li A, Xiao C, Huang G, Worden K, Muroy S, Chen W, Xu Z, Tso CF, Huang Y, Zhang Y, Luo Q, ... ... Dan Y, et al. Microglia regulate sleep through calcium-dependent modulation of norepinephrine transmission. Nature Neuroscience. PMID 38238430 DOI: 10.1038/s41593-023-01548-5

3. Li B, Ma C, Huang YA, Ding X, Silverman D, Chen C, Darmohray D, Lu L, Liu S, Montaldo G, Urban A, Dan Y. Circuit mechanism for suppression of frontal cortical ignition during NREM sleep. Cell. PMID 38070510 DOI: 10.1016/j.cell.2023.11.012

4. Yao Y, Barger Z, Saffari Doost M, Tso CF, Darmohray D, Silverman D, Liu D, Ma C, Cetin A, Yao S, Zeng H, Dan Y. Cardiovascular baroreflex circuit moonlights in sleep control. Neuron. PMID 36170850 DOI: 10.1016/j.neuron.2022.08.027

5. Hu F, Dan Y. An inferior-superior colliculus circuit controls auditory cue-directed visual spatial attention. Neuron. PMID 34699777 DOI: 10.1016/j.neuron.2021.10.004

6. Li B, Nguyen TP, Ma C, Dan Y. Inhibition of impulsive action by projection-defined prefrontal pyramidal neurons. Proceedings of the National Academy of Sciences of the United States of America. PMID 32631999 DOI: 10.1073/pnas.2000523117

7. Liu D, Li W, Ma C, Zheng W, Yao Y, Tso CF, Zhong P, Chen X, Song JH, Choi W, Paik SB, Han H, Dan Y. A common hub for sleep and motor control in the substantia nigra. Science (New York, N.Y.). 367: 440-445. PMID 31974254 DOI: 10.1126/Science.Aaz0956

8. Hu F, Kamigaki T, Zhang Z, Zhang S, Dan U, Dan Y. Prefrontal Corticotectal Neurons Enhance Visual Processing through the Superior Colliculus and Pulvinar Thalamus. Neuron. PMID 31668485 DOI: 10.1016/J.Neuron.2019.09.019

9. Zhong P, Zhang Z, Barger Z, Ma C, Liu D, Ding X, Dan Y. Control of Non-REM Sleep by Midbrain Neurotensinergic Neurons. Neuron. PMID 31582313 DOI: 10.1016/j.neuron.2019.08.026

10. Ma C, Zhong P, Liu D, Barger ZK, Zhou L, Chang WC, Kim B, Dan Y. Sleep Regulation by Neurotensinergic Neurons in a Thalamo-Amygdala Circuit. Neuron. PMID 31178114 DOI: 10.1016/j.neuron.2019.05.015

11. Zhang Z, Zhong P, Hu F, Barger Z, Ren Y, Ding X, Li S, Weber F, Chung S, Palmiter RD, Dan Y. An Excitatory Circuit in the Perioculomotor Midbrain for Non-REM Sleep Control. Cell. PMID 31031008 DOI: 10.1016/J.Cell.2019.03.041

12. Liu D, Dan Y. A Motor Theory of Sleep-Wake Control: Arousal-Action Circuit. Annual Review of Neuroscience. PMID 30699051 DOI: 10.1146/annurev-neuro-080317-061813

13. Chen KS, Xu M, Zhang Z, Chang WC, Gaj T, Schaffer DV, Dan Y. A Hypothalamic Switch for REM and Non-REM Sleep. Neuron. PMID 29478915 DOI: 10.1016/J.Neuron.2018.02.005

14. Weber F, Hoang Do JP, Chung S, Beier KT, Bikov M, Saffari Doost M, Dan Y. Regulation of REM and Non-REM Sleep by Periaqueductal GABAergic Neurons. Nature Communications. 9: 354. PMID 29367602 DOI: 10.1038/S41467-017-02765-W

15. Chung S, Weber F, Zhong P, Tan CL, Nguyen TN, Beier KT, Hörmann N, Chang WC, Zhang Z, Do JP, Yao S, Krashes MJ, Tasic B, Cetin A, Zeng H, ... ... Dan Y, et al. Identification of preoptic sleep neurons using retrograde labelling and gene profiling. Nature. PMID 28514446 DOI: 10.1038/Nature22350

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