主要运用结构生物学、生物化学、生理学等手段，从事与重大疾病相关的膜蛋白的工作机理和药物作用机制的研究，目前开展的方向包括代谢疾病相关的膜蛋白以及肿瘤-免疫相关的蛋白的研究。

潘孝敬，深圳医学科学院特聘研究员，国家自然科学基金优秀青年基金获得者。自博士后工作开始，先后获得中国博士后基金会的“博新计划”，国自然的青年基金，面上项目，北京市科委的“科技新星”等经费支持。潘孝敬在国际顶级学术期刊Science上以第一作者（含共一）发表文章5篇，以共通讯作者在PNAS、Nature Communications等杂志发表文章8篇。

2021     中国博士后基金会优秀创新成果

2019     北京市科委评选“科技新星”

2019     清华大学结构生物学高精尖中心卓越青年科学家

2018     清华大学优秀博士后

2016     中国博士后基金会“博新计划”

2016     北京市优秀毕业生

2013     教育部博士生国家奖学金

2012     教育部硕士生国家奖学金

2012     教育部第十七届博士生学术新人奖

2012     清华大学“蒋南翔”奖学金

2011     安徽省优秀毕业生，中国科学技术大学优秀毕业生

*代表共同第一作者，#代表共同通讯作者。

1.Wu, Q.^*, Huang, J.^*#, Fan, X.^*#, Wang, K.^*, Jin, X., Huang, G., Li, J., Pan, X.^# and Yan, N.^#, 2023. Structural mapping of Nav1. 7 antagonists. Nature Communications, 14(1), p.3224.

2.Huang, G.^*, Wu, Q.^*, Li, Z.^*, Jin, X.^*, Huang, X., Wu, T., Pan, X.^#and Yan, N.^#, 2022. Unwinding and spiral sliding of S4 and domain rotation of VSD during the electromechanical coupling in Nav1. 7. Proceedings of the National Academy of Sciences, 119(33), p.e2209164119.

3.Huang, X.^*, Jin, X.^*, Huang, G., Huang, J., Wu, T., Li, Z., Chen, J., Kong, F., Pan, X.^# and Yan, N.^#, 2022. Structural basis for high-voltage activation and subtype-specific inhibition of human Nav1. 8. Proceedings of the National Academy of Sciences, 119(30), p.e2208211119.

4.Pan, X.^*#, Li, Z.^*, Jin, X.^*, Zhao, Y.^*, Huang, G.^*, Huang, X., Shen, Z., Cao, Y., Dong, M., Lei, J. and Yan, N.^#, 2021. Comparative structural analysis of human Nav1. 1 and Nav1. 5 reveals mutational hotspots for sodium channelopathies. Proceedings of the National Academy of Sciences, 118(11), p.e2100066118.

5.Li, Z., Jin, X., Wu, T., Zhao, X., Wang, W., Lei, J., Pan, X.^# and Yan, N.^#, 2021. Structure of human Nav1. 5 reveals the fast inactivation-related segments as a mutational hotspot for the long QT syndrome. Proceedings of the National Academy of Sciences, 118(11), p.e2100069118.

6.Shen, H.^#, Yan, N.^# and Pan, X.^#, 2021. Structural determination of human Nav1. 4 and Nav1. 7 using single particle cryo-electron microscopy. Methods in Enzymology (Vol. 653, pp. 103-120). Academic Press.

7.Chi, X.^*, Jin, X.^*, Chen, Y.^*, Lu, X., Tu, X., Li, X., Zhang, Y., Lei, J., Huang, J., Huang, Z.^#, Zhou, Q.^#, and Pan, X.^#, 2020. Structural insights into the gating mechanism of human SLC26A9 mediated by its C-terminal sequence. Cell Discovery, 6(1), p.55.

8.Pan, X.^*, Li, Z.^*, Huang, X.^*, Huang, G.^*, Gao, S., Shen, H., Liu, L., Lei, J. and Yan, N., 2019. Molecular basis for pore blockade of human Na+ channel Nav1. 2 by the μ-conotoxin KIIIA. Science, 363(6433), pp.1309-1313.

9.Pan, X.^*, Li, Z.^*, Zhou, Q.^*, Shen, H.^*, Wu, K.^*, Huang, X., Chen, J., Zhang, J., Zhu, X., Lei, J. and Xiong, W., Gong, H., Xiao, B., and Yan, N., 2018. Structure of the human voltage-gated sodium channel Nav1. 4 in complex with β1. Science.362(6412), p.eaau2486.

10.Shen, H.^*, Li, Z.^*, Jiang, Y.^*, Pan, X.^*, Wu, J., Cristofori-Armstrong, B., Smith, J.J., Chin, Y.K., Lei, J., Zhou, Q.^# and King, G.F.^#, and Yan, N.^#, 2018. Structural basis for the modulation of voltage-gated sodium channels by animal toxins. Science, 362(6412), p.eaau2596.

11.Shen, H.^*, Zhou, Q.^*, Pan, X.^*, Li, Z.^*, Wu, J. and Yan, N., 2017. Structure of a eukaryotic voltage-gated sodium channel at near-atomic resolution. Science, 355(6328), p.eaal4326.

12.Deng, D.^*, Yan, C.^*, Pan, X.^*, Mahfouz, M., Wang, J., Zhu, J.K., Shi, Y.^# and Yan, N.^#, 2012. Structural basis for sequence-specific recognition of DNA by TAL effectors. Science, 335(6069), pp.720-723.

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