苏稚盈教授曾任美国加州大学圣地亚哥分校（UC San Diego）神经生物学系教授及副系主任，并于2026年7月以资深研究员身份加入深圳医学科学院（SMART）。苏稚盈于约翰斯·霍普金斯大学获得神经科学博士学位，并在耶鲁大学完成博士后研究，长期致力于探索神经系统如何感知和处理外界信息，以及这些过程如何塑造动物行为。苏稚盈的研究聚焦于嗅觉信息处理与神经调质机制，尤其关注感觉系统在信息处理初级阶段的动态调控。相关研究发表于国际神经科学与生物学领域的重要期刊，包括Nature、Neuron、Nature Communications和PNAS。

主要奖项与荣誉

2016 Faculty Mentorship Award, Division of Biological Sciences, UCSD

2015 Ray Thomas Edwards Foundation Career Award 

2015 Hellman Fellowship

2013 AChemS ECRO Fellowship, Association for Chemoreception Sciences 

2006 Phi Beta Kappa Society, Johns Hopkins University 

2006 Young Investigator Award, Johns Hopkins University School of Medicine

课题组研究方向

课题组以果蝇（Drosophila）为模式生物，关注一个核心问题：神经系统如何在复杂且不断变化的环境中，高效地提取、调控并利用感觉信息，从而产生合适的行为反应。课题组重点研究嗅觉系统在感觉信息处理初级阶段的神经机制，以及神经调质如何动态改变感觉神经元活性，并进一步影响下游神经环路与动物行为。

这一问题在嗅觉系统中尤具挑战性。与视觉可通过有限波长组合描述颜色不同，气味分子缺乏简单且统一的“维度”定义，天然气味往往由大量复杂化学成分组成，使嗅觉信息编码与识别成为神经科学中的重要难题。嗅觉也是少数难以被直接数字化的感觉系统之一——人们可以通过手机传送图片，却无法真正“传送一种气味”。因此，课题组希望理解神经系统如何在有限神经元资源下，高效完成对复杂气味世界的检测、编码与行为决策。

课题组特别关注这样一个问题：为什么像果蝇这样仅拥有远少于哺乳动物神经元数量的简单神经系统，仍能实现高度高效且灵活的信息处理。由于感觉输入层的微小调控即可对后续神经环路与行为产生深远影响，我们希望通过研究感觉系统的“输入端计算”，理解神经系统高效运作的基本原则，并为数据科学中的高效信息处理与计算策略提供启发。

课题组结合遗传学、电生理、钙成像、行为分析和电子显微镜等技术，开展从分子、细胞到神经环路层面的综合研究。

代表论文

1. Intrinsic diversity in odor-evoked calcium rises across Drosophila olfactory neurons. Yiyi Xiao, Shiuan-Tze Wu, Renny Ng and Chih-Ying Su*. Journal of Neuroscience. 2026, 46(18), e2132252026. 

2. Morphological specializations of mosquito CO2-sensing olfactory receptor neurons. Shadi Charara^#, Jonathan Choy^#, Kalyani Cauwenberghs, Pawel Vijayakumar, Renny Ng, Keun-Young Kim, Shih-Che Weng, Omar S Akbari, Mark H Ellisman, Scott A Rifkin and Chih-Ying Su*. Proceedings of the National Academy of Sciences of the United States of America. 2025, 122 (43), e2514666122.

3. Peripheral preprocessing in Drosophila facilitates odor classification. Palka Puri, Shiuan-Tze Wu, Chih-Ying Su, and Johnatan Aljadeff*. Proceedings of the National Academy of Sciences of the United States of America. 2024, 121(21), e2316799121.

4. Valence opponency in peripheral olfactory processing. Shiuan-Tze Wu^#, Jen-Yung Chen^#, Vanessa Martin, Renny Ng, Ye Zhang, Dhruv Grover, Ralph J Greenspan, Johnatan Aljadeff and Chih-Ying Su*. Proceedings of the National Academy of Sciences of the United States of America. 2022, 119(5), e2120134119.

5. Systematic morphological and morphometric analysis of identified olfactory receptor neurons in Drosophila melanogaster. Cesar Nava Gonzales^#, Quintyn McKaughan^#, Eric A Bushong, Kalyani Cauwenberghs, Renny Ng, Matthew Madany, Mark H Ellisman and Chih-Ying Su*. Elife. 2021, 10, e69896.

6. Amplification of Drosophila olfactory responses by a DEG/ENaC channel. Renny Ng, Secilia S Salem, Shiuan-Tze Wu, Meilin Wu, Hui-Hao Lin, Andrew K Shepherd, William J Joiner, Jing W Wang and Chih-Ying Su*. Neuron. 2019, 104(5), 947-959.

7. Asymmetric ephaptic inhibition between compartmentalized olfactory receptor neurons. Ye Zhang^#, Tin Ki Tsang^#, Eric A Bushong, Li-An Chu, Ann-Shyn Chiang, Mark H Ellisman, Jürgen Reingruber and Chih-Ying Su*. Nature Communications. 2019, 10(1), 1-16.

8. Hormonal modulation of pheromone detection enhances male courtship success. Hui-Hao Lin^#, De-Shou Cao^#, Sachin Sethi, Zheng Zeng, Jacqueline SR Chin, Tuhin Subhra Chakraborty, Andrew K Shepherd, Christine A Nguyen, Joanne Y Yew, Chih-Ying Su*, Jing W Wang*. Neuron. 2016, 90(6),1272-1285.

9. Non-synaptic inhibition between grouped neurons in an olfactory circuit. Chih-Ying Su, Karen Menuz, Johannes Reisert, John R Carlson*. Nature. 2012, 492(7427), 66-71.

10. Olfactory perception: receptors, cells, and circuits. Chih-Ying Su^#, Karen Menuz^#, John R Carlson*. Cell. 2009, 139(1), 45-59.