SMART Fellow
Principal Investigator
Computational Protein Design
wyang@smart.org.cn
2025 - PresentPrincipal Investigator, Shenzhen Medical Academy of Research and Translation (SMART)
2019 - 2025Postdoctoral Fellow, University of Washington, Seattle, USA
2012 - 2019Ph.D. Tsinghua University (PTN Joint Program) Ph.D., Beijing, China
2008 - 2012B.S. Huazhong University of Science and Technology School of Life Science and Technology, Wuhan, China
The Protein Therapeutic Design Laboratory at the Shenzhen Medical Academy of Reseach and Translations is dedicated to developing computational methods for designing novel protein therapeutics. The lab aims at pushing de novo designed protein therapeutis such as immune checkpoint inhibitors, cytokines mimics, and enzymes to clinical translations via comprehensive approaches.
1. Yang, W., Sun, X., Zhang, C. & Lai, L. Discovery of novel helix binding sites at protein-protein interfaces. Comput. Struct. Biotechnol. J. 17, 1396–1403 (2019).
2. Yang, W. et al. Computational design and optimization of novel d-peptide TNFα inhibitors. FEBS Lett. 593, 1292–1302.
3. Yang, W. et al. Design of high-affinity binders to immune modulating receptors for cancer immunotherapy. Nat. Commun. 16, 2001 (2025).
4. Cao, L. et al. Design of protein-binding proteins from the target structure alone. Nature605, 551–560 (2022).
5. Wang, J. et al. Scaffolding protein functional sites using deep learning. Science 377, 387–394 (2022).
