The Protein Therapeutic Design Laboratory at the Shenzhen Medical Academy of Reseach and Translations is dedicated to developing  computational methods for designing novel protein therapeutics. The lab aims at pushing de novo designed protein therapeutis such as immune checkpoint inhibitors, cytokines mimics, and enzymes to clinical translations via comprehensive approaches. 

Dr. Wei Yang specializes in developing novel computational design methods for protein-protein interactions, with applications in immune regulation, cancer immunotherapy, and blood-brain barrier transport. He has published 16 peer-reviewed articles in prestigious journals such as Nature Communications and Chemical Science.

1. Yang, W., Sun, X., Zhang, C. & Lai, L. Discovery of novel helix binding sites at protein-protein interfaces. Comput. Struct. Biotechnol. J. 17, 1396–1403 (2019).

2. Yang, W. et al. Computational design and optimization of novel d-peptide TNFα inhibitors. FEBS Lett. 593, 1292–1302.

3. Yang, W. et al. Design of high-affinity binders to immune modulating receptors for cancer immunotherapy. Nat. Commun. 16, 2001 (2025).

4. Cao, L. et al. Design of protein-binding proteins from the target structure alone. Nature605, 551–560 (2022).

5. Wang, J. et al. Scaffolding protein functional sites using deep learning. Science 377, 387–394 (2022).

https://mp.weixin.qq.com/s/hWlE2rNzM6r2kLogjC8XYw