Immune receptors play a crucial role in human immunity and are important therapeutic targets for tumor immunotherapy and autoimmune diseases. Our group mainly uses diverse techniques such as biochemistry, immunology, cell biology, and structural biology to explore the working principles of important immune receptors. We will combine biochemical and structural analysis to design and screen antibodies that target immune receptors, aiming to precisely regulate immune cell functions. Moreover, we will conduct preclinical studies on these antibodies, primarily applying them in key areas such as tumors and infectious diseases. In addition to these goals, we will design and improve new immune receptor ligands based on the working mechanism of immune receptors. We hope to apply these new immune receptor ligands in immunotherapy, thereby promoting the development of a new generation of immunotherapy treatments. Our main research directions are as follows:

1. Molecular mechanisms of key immune receptors

2. Development of specific antibodies against key immune receptors

3. Design of new immune receptor ligands

Dr. Su Qiang has extensive experience in the research of structural biology of immune receptors, and has published papers as the first or corresponding author in Nature (1 paper, 2024), Science (2 papers, 2022, 2018), and Nature Communications (2 papers, 2021, 2018). He has also published 4 papers in Cell Discovery, Cell Research, PNAS, etc. as the co-first author and other authors.

2022 Outstanding Postdoctoral Fellow, Westlake University

2019 Outstanding Doctoral Student, Center for Advanced Studies, Tsinghua University

Served as an independent reviewer for international renowned journals Signal Transduction and Targeted Therapy (IF: 38.1), Allergy (IF: 12.4).

#for co-corresponding author.

1.Weizhi Xin, Bangdong Huang, Ximin Chi, Yuehua Liu, Mengjiao Xu, Yuanyuan Zhang, Xu Li, Qiang Su^#, and Qiang Zhou^#. (2024). Structures of human γδ T cell receptor–CD3 complex. Nature. Online ahead of print.(#corresponding author)

2.Zhifei Wang, Mengying Chen, Qiang Su, Tiago D. C. Morais, Yan Wang, Elianna Nazginov, Akhilraj R. Pillai, Feng Qian, Yigong Shi and Yong Yu^#. (2024). Molecular and structural basis of the dual regulation of the polycystin-2 ion channel by small-molecule ligands. PNAS. 121(12): e2316230121.

3.Qiang Su^#, Mengying Chen, Yan Shi, Xiaofeng Zhang, Gaoxingyu Huang, Bangdong Huang, Dongwei Liu, Zhangsuo Liu, and Yigong Shi^#. (2022). Cryo-EM structure of the human IgM B cell receptor. Science. 337(6608):875-880.(#corresponding author)

4.Qiang Su^#, Mengying Chen, Yan Wang, Bin Li, Dan Jing, Xiechao Zhan, Yong Yu, and Yigong Shi^#. (2021). Structural basis for Ca²⁺ activation of the heteromeric PKD1L3/PKD2L1 channel. Nature Communications. 12(1):4871.(#corresponding author)

5.Meng Ke, Yue Yu, Changjian Zhao, Shirong Lai, Qiang Su, Weidan Yuan, Lina Yang, Dong Deng, Kun Wu, Weizheng Zeng, Jia Geng, Jianping Wu and Zhen Yan^#. (2021). Cryo-EM structures of human TMEM120A and TMEM120B. Cell Discovery. 7(1):77.

6.Ximin Chi, Xiaorong Li, Yun Chen, Yuanyuan Zhang, Qiang Su, and Qiang Zhou^#. (2020). Cryo-EM structures of the full-length human KCC2 and KCC3 cation-chloride cotransporters. Cell Research. 31(4):482-484.

7.Qiang Su, Feizhuo Hu, Xiaofei Ge, Jianlin Lei, Shengqiang Yu, Tingliang Wang, Qiang Zhou, Changlin Mei and Yigong Shi^#. (2018). Structure of the human PKD1-PKD2 complex. Science. 361(6406):eaat9819.

8.Qiang Su, Feizhuo Hu, Yuxia Liu, Xiaofei Ge, Changlin Mei, Shengqiang Yu, Aiwen Shen, Qiang Zhou, Chuangye Yan, Jianlin Lei, Yanqing Zhang^#, Xiaodong Liu^# and Tingliang Wang^#. (2018). Cryo-EM structure of the polycystic kidney disease-like channel PKD2L1. Nature Communications. 9(1):1192.

https://smart.org.cn/recruit/research-team/content/post_1139637.html