主要运用结构生物学、生物化学、生理学等手段，从事与重大疾病相关的膜蛋白的工作机理和药物作用机制的研究，目前开展的方向包括代谢疾病相关的膜蛋白以及肿瘤-免疫相关的蛋白的研究。潘孝敬博士在国际顶级学术期刊Science上以第一作者（含共一）发表文章5篇，以共通讯作者在PNAS，Nature Communications等杂志发表文章9篇。

2021     中国博士后基金会优秀创新成果

2019     北京市科委评选“科技新星”

2019     清华大学结构生物学高精尖中心卓越青年科学家

2018     清华大学优秀博士后

2016     中国博士后基金会“博新计划”

2016     北京市优秀毕业生

2013     教育部博士生国家奖学金

2012     教育部硕士生国家奖学金

2012     教育部第十七届博士生学术新人奖

2012     清华大学“蒋南翔”奖学金

2011     安徽省优秀毕业生，中国科学技术大学优秀毕业生

*代表共同第一作者，#代表共同通讯作者。

1.Huang, J., Pan, X.^#,  Yan, N^#. 2024. Structural biology and molecular pharmacology of voltage-gated ion channels. Nature Reviews Molecular Cell Biology, 1-22.

2.Shen, Z. *, Xu, L. *, Wu, T. *, Wang, H. *, Wang, Q., Ge, X., Huang, G., Pan, X.^#. 2024. Structural basis for urate recognition and apigenin inhibition of human GLUT9. Nature Communications, 15(1), 5039.

3.Wu, Q.*, Huang, J.*^#, Fan, X.*^#, Wang, K.*, Jin, X., Huang, G., Li, J., Pan, X.^# and Yan, N.^#, 2023. Structural mapping of Nav1. 7 antagonists. Nature Communications, 14(1), p.3224.

4.Huang, G.*, Wu, Q.*, Li, Z.*, Jin, X.*, Huang, X., Wu, T., Pan, X.^# and Yan, N.^#, 2022. Unwinding and spiral sliding of S4 and domain rotation of VSD during the electromechanical coupling in Nav1. 7. Proceedings of the National Academy of Sciences, 119(33), p.e2209164119.

5.Huang, X.*, Jin, X.*, Huang, G., Huang, J., Wu, T., Li, Z., Chen, J., Kong, F., Pan, X.^# and Yan, N.^#, 2022. Structural basis for high-voltage activation and subtype-specific inhibition of human Nav1. 8. Proceedings of the National Academy of Sciences, 119(30), p.e2208211119.

6.Pan, X.*^#, Li, Z.*, Jin, X.*, Zhao, Y.*, Huang, G.*, Huang, X., Shen, Z., Cao, Y., Dong, M., Lei, J. and Yan, N.^#, 2021. Comparative structural analysis of human Nav1. 1 and Nav1. 5 reveals mutational hotspots for sodium channelopathies. Proceedings of the National Academy of Sciences, 118(11), p.e2100066118.

7.Li, Z., Jin, X., Wu, T., Zhao, X., Wang, W., Lei, J., Pan, X.^# and Yan, N.^#, 2021. Structure of human Nav1. 5 reveals the fast inactivation-related segments as a mutational hotspot for the long QT syndrome. Proceedings of the National Academy of Sciences, 118(11), p.e2100069118.

8.Shen, H.^#, Yan, N.^# and Pan, X.^#, 2021. Structural determination of human Nav1. 4 and Nav1. 7 using single particle cryo-electron microscopy. Methods in Enzymology (Vol. 653, pp. 103-120). Academic Press.

9.Chi, X.*, Jin, X.*, Chen, Y.*, Lu, X., Tu, X., Li, X., Zhang, Y., Lei, J., Huang, J., Huang, Z.^#, Zhou, Q.^#, and Pan, X.^#, 2020. Structural insights into the gating mechanism of human SLC26A9 mediated by its C-terminal sequence. Cell Discovery, 6(1), p.55.

10.Pan, X.*, Li, Z.*, Huang, X.*, Huang, G.*, Gao, S., Shen, H., Liu, L., Lei, J. and Yan, N., 2019. Molecular basis for pore blockade of human Na+ channel Nav1. 2 by the μ-conotoxin KIIIA. Science, 363(6433), pp.1309-1313.

11.Pan, X.*, Li, Z.*, Zhou, Q.*, Shen, H.*, Wu, K.*, Huang, X., Chen, J., Zhang, J., Zhu, X., Lei, J. and Xiong, W., Gong, H., Xiao, B., and Yan, N., 2018. Structure of the human voltage-gated sodium channel Nav1. 4 in complex with β1. Science.362(6412), p.eaau2486.

12.Shen, H.*, Li, Z.*, Jiang, Y.*, Pan, X.*, Wu, J., Cristofori-Armstrong, B., Smith, J.J., Chin, Y.K., Lei, J., Zhou, Q.^#and King, G.F.^#, and Yan, N.^#, 2018. Structural basis for the modulation of voltage-gated sodium channels by animal toxins. Science, 362(6412), p.eaau2596.

13.Shen, H.*, Zhou, Q.*, Pan, X.*, Li, Z.*, Wu, J. and Yan, N., 2017. Structure of a eukaryotic voltage-gated sodium channel at near-atomic resolution. Science, 355(6328), p.eaal4326.

14.Deng, D.*, Yan, C.*, Pan, X.*, Mahfouz, M., Wang, J., Zhu, J.K., Shi, Y.^#and Yan, N.^#, 2012. Structural basis for sequence-specific recognition of DNA by TAL effectors. Science, 335(6069), pp.720-723.