蛋白质翻译后修饰(PTMs)在先天免疫调控中的作用机制研究，通过开发创新蛋白质组学技术，系统探索了病毒感染和肿瘤免疫两大关键领域。

1. 系统阐明蛋白质乙酰化在抗病毒先天免疫中的关键作用。绘制了人巨细胞病毒全周期乙酰化时空图谱；发现核纤层蛋白乙酰化通过维持核膜完整性广谱抑制病毒复制；揭示线粒体去乙酰化酶SIRT3通过调控线粒体功能抑制病毒复制的新机制。

2. 开创性解析病毒微环境中细胞间通讯机制。开发空间分辨蛋白质组学方法，首次证实邻近感染细胞通过细胞外基质重塑形成"病毒易感态"，揭示病毒免疫逃逸新途径。

3. 发现肿瘤缺氧微环境中乳酸化修饰驱动免疫逃逸的关键机制。揭示LDHA-GTPSCS轴通过驱动组蛋白乳酸化促进巨噬细胞M2极化，为肿瘤免疫治疗提供新靶点。

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