发掘预防与治疗传染性疾病的生物靶点。课题组主要探讨机体内病原微生物的致病机理；探讨宿主免疫系统、细胞代谢防御病原微生物的分子机理。包括：1.病原微生物的致病机理；2.机体抵抗病原微生物感染的分子机理；3.新抗菌分子的筛选和鉴定。课题组学术氛围浓厚，成员和谐友爱，共同进步，欢迎对感染、免疫、代谢等研究内容感兴趣的同学或研究人员加入我们课题组。

近期代表性论:

Meng, Q.#, Li, C.#, Cai, Y., Chen, Y., Chen, X., Wang, X., Zhang, B., Zhang, Y., Liu, F., Chen, M*. (2025). Itaconate transport across the plasma membrane and Salmonella-containing vacuole via MCT1/4 modulates macrophage antibacterial activity. Nature Communications, 16 (1), 10551.

Chen, M.#, Sun, H. #, Boot, M., Shao, L., Chang, S.J., Wang, W., Lam, T.T., Lara-Tejero, M., Rego, E.H. and Galán, J.E. *, 2020. Itaconate is an effector of a Rab GTPase cell-autonomous host defense pathway against Salmonella. Science, 369(6502), pp.450-455.    

Lian, H. #, Park, D. #, Chen, M., Schueder, F., Lara-Tejero, M., Liu, J., & Galán, J. E*, 2023. Parkinson’s disease kinase LRRK2 coordinates a cell-intrinsic itaconate-dependent defence pathway against intracellular Salmonella. Nature Microbiology, 1-16.

Chen, M.#, Zhao, Z. #, Meng, Q. #, Liang, P. #, Su, Z., Wu, Y., Huang, J. and Cui, J. *, 2019. TRIM14 Promotes Noncanonical NF‐kB Activation by Modulating p100/p52 Stability via Selective Autophagy. Advanced Science, p.1901261.

Chen, M.#, Meng, Q. #, Qin, Y. #, Liang, P., Tan, P., He, L., Zhou, Y., Chen, Y., Huang, J. *, Wang, R.F. * and Cui, J. *, 2016. TRIM14 inhibits cGAS degradation mediated by selective autophagy receptor p62 to promote innate immune responses. Molecular Cell, 64(1), pp.105-119.