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宗晖
宗晖

资深研究员

研究领域

基于小鼠遗传嵌合体的癌症模型,胶质瘤,细胞-细胞相互作用

个人邮箱

huizong@szbl.ac.cn

教育与工作经历

2026-至今 深圳湾实验室 肿瘤研究所 资深研究员

2023-2026 弗吉尼亚大学 微生物、免疫、癌症生物学系,正教授

2013-2023 弗吉尼亚大学 微生物、免疫、癌症生物学系,副教授

2007-2012 俄勒冈大学 生物系,分子生物学所,助理教授

2001-2006 斯坦福大学 博士后

1996-2001 印第安纳大学医学院 生物化学和分子生物学系,博士

1993-1996 复旦大学 硕士

1989-1993 复旦大学 学士

研究方向
研究领域

利用小鼠遗传嵌合体模型、以极高的时空分辨率来研究肿瘤的起源和恶化过程,借以研发癌症预防和精准治疗的手段,从根本上改善疗效并提高病人的生活质量。

成果荣誉

2022 皮尤创新奖,皮尤慈善信托基金(美国共6支队伍)

2020 弗吉尼亚大学医学院 Pinn 学者(该校共 3 名)

2011 Richard T. Jones 新研究员奖,医学研究基金会,俄勒冈健康与科学大学(俄勒冈州共 1 人)

2008 皮尤生物医学科学学者,皮尤慈善信托基金(美国共 20 位)

代表论文

1.Jiang Y#*, Ahn R#, Huang A, Gonzalez PP, Kim J, Zhang G, Liu Z, He Z, Dudley L, Patel KS, Crowl S, Przanowski P, Quesada-Camacho L, Hao S, Zeng J, Fallahi-Sichani M, Janes KA, Naegle KM, Goldman SA, Kornblum KI, Yao M*, White F*, Zong H* (2026) Critical role of cell competition in gliomagenesis. bioRxiv [Preprint]. 2026 Jan 16:2026.01.15.699808.

2.Zeng J, Singh S, Jiang Y, Casarez E, Atkins KA, Janes KA, Zong H* (2023) A genetic mosaic mouse model illuminates the pre-malignant progression of basal-like breast cancer. Disease Models and Mechanisms, 16, dmm050219. doi:10.1242/dmm.050219, PMC10168298

3.Zeng J, Alvarez-Yela AC, Casarez E, Jiang Y, Wang L, Kelly BE, Ke E, Jenkins T, Atkins KA, Janes KA, Slack-Davis JK*, Zong H* (2023) Dichotomous ovarian cancer-initiating potential of Pax8+ cells revealed by a mouse genetic mosaic model. iScience (Cell Press), 26(5) 106742. PMC10189502

4.Yao M, Ventura PB, Jiang Y, Rodriguez FJ, Wang L, Perry JSA, Yang Y, Wahl K, Crittenden RB, Bennett ML, Qi L, Gong C, Li X, Barres BA, Bender TP, Ravichandran K, Janes KA, Eberhart CG, Zong H* (2020) Astrocytic trans-differentiation completes a multicellular paracrine feedback loop required for medulloblastoma tumor growth. Cell, 180(3):502-520 DOI: 10.1016/j.cell.2019.12.024. PMC7259679

5.Gonzalez PP, Kim J, Galvao RP, Cruickshanks N, Abounader R, and Zong H.* (2018) p53 and NF1 loss plays distinct but complementary roles in glioma initiation and progression. Glia, 66(5):999-1015. PMC7808243

6.Ledur P, Liu C, He H, Harris A, Minussi D, Zhou H, Shaffrey M, Asthagiri A, Lopes M, Schiff D, Lu Y, Mandell J, Lenz G, Zong H.* (2016) Culture conditions tailored to the cell of origin are critical for maintaining native properties and tumorigenicity of glioma cells Neuro-Oncology, 18(10):1413-24. PMC5035523

7.Galvao, R.P., Kasina, A., McNeill, R.S., Harbin, J.E., Foreman, O., Verhaak, R.G.W., Nishiyama, A., Miller, C.R., Zong, H.* (2014) Transformation of quiescent adult oligodendrocyte precursor cells into malignant glioma through a multi-step reactivation process. PNAS, 111(40):E4214-23. PMC4210043

8.Liu, C., Sage, J.C., Miller, M.R., Verhaak, R.G.W., Hippenmeyer, S., Vogel, H., Foreman, O., Bronson, R.T., Nishiyama, A., Luo, L., Zong, H.* (2011) Mosaic Analysis with Double Markers Reveals Tumor Cell-of-Origin in Glioma. Cell, 146:209-221. PMC3143261

9.Muzumdar, M.D., Luo, L., Zong, H* (2007) Modeling sporadic loss of heterozygosity in mice by using mosaic analysis with double markers (MADM). PNAS, 104:4495-4500. PMC1810340

10.Zong, H., Espinosa, S., Su, H., Muzumdar, M.D., and Luo, L* (2005) Mosaic analysis with double markers in mice. Cell, 121:479-492