个人简介

盛心磊博士于2013年获清华大学生命科学学士学位，2021年获普林斯顿大学分子生物学博士学位。获得博士学位后，先后于普林斯顿大学（2021.07-2021.11）和芝加哥大学（2021.12-2025.10）从事博士后研究。2025年11月全职加入深圳医学科学院，任特聘研究员。

盛心磊博士多年来始终聚焦蛋白质翻译后修饰（PTMs）在先天免疫调控中的作用机制研究，通过开发创新蛋白质组学技术，系统探索了病毒感染和肿瘤免疫两大关键领域中PTMs的作用，为发展精准医疗技术奠定了重要基础。

课题组研究方向

盛心磊课题组将立足于蛋白质翻译后修饰（PTMs）和先天免疫调控研究，发挥其在蛋白质组学技术开发方面的优势，深入研究在病毒感染过程中和免疫细胞内翻译后修饰的功能和调控机制，深化“生物医学+人工智能”交叉研究，推动蛋白质组学驱动的精准医疗创新。

主要论文集

* Equal contributions

1. Sheng, X., Lin, H., Cole, C.A., Zhao, Y. (2025). Biochemistry and regulation of histone lysine L-lactylation. Nature Reviews Molecular Cell Biology.

2. Gao, Y., Sheng, X.*, Tan, D., Kim, S., Choi, S., Paudel, S., Lee, T., Yan, C., Tan, M., Kim, K.M., Cho, S.S., Ki, S.H., Huang, H., Zhao, Y., Lee, S. (2023). Identification of Histone Lysine Acetoacetylation as a Dynamic Post-Translational Modification Regulated by HB01. Advanced Science.

3. Song, B., Sheng, X.*, Justice, J.L., Lum, K.K., Metzger, P.J., Cook, K.C., Kostas, J.C., Cristea, I.M. (2023). Intercellular communication within the virus microenvironment affects the susceptibility of cells to secondary viral infections. Science Advances.

4. Shi, W., Sheng, X.*, Dorr, K.M., Hutton, J.E., Emerson, J.I., Davies, H.A., Andrade, T.D., Wasson, L.K., Greco, T.M., Hashimoto, Y., Federspiel, J.D., Robbe, Z.L., Chen, X., Arnold, A.P., Cristea, I.M., Conlon, F.L. (2021). Cardiac proteomics reveals sex chromosome-dependent differences between males and females that arise prior to gonad formation. Developmental Cell.

5. Sheng, X., Cristea, I.M. (2021). The antiviral sirtuin 3 bridges protein acetylation to mitochondrial integrity and metabolism during human cytomegalovirus infection. PLoS Pathogens.

Personal Profile 

Dr. SHENG Xinlei received his Bachelor's degree in Life Sciences from Tsinghua University in 2013 and his Ph.D. in Molecular Biology from Princeton University in 2021. After obtaining his Ph.D., he conducted postdoctoral research at Princeton University (July 2021 – November 2021) and the University of Chicago (December 2021 – October 2025). In November 2025, he joined the Shenzhen Medical Academy of Research and Translation as a Junior Principal Investigator.

Over the years, Dr. SHENG has focused on elucidating the molecular mechanisms of protein post-translational modifications (PTMs) in the regulation of innate immunity. By developing innovative proteomics technologies, he has systematically explored the roles of PTMs in viral infection and tumor immunology, laying a solid foundation for the advancement of precision medicine.

Research Directions of the Group

Dr. SHENG's research group will continue to center on PTMs and innate immune regulation, leveraging its strengths in proteomics technology development to investigate the functional and regulatory mechanisms of PTMs during viral infection and within immune cells. The group will also deepen interdisciplinary research combining biomedicine and artificial intelligence, driving innovation in proteomics-driven precision medicine.

Representative Publications

* Equal contributions

1. Sheng, X., Lin, H., Cole, C.A., Zhao, Y. (2025). Biochemistry and regulation of histone lysine L-lactylation. Nature Reviews Molecular Cell Biology.

2. Gao, Y., Sheng, X.*, Tan, D., Kim, S., Choi, S., Paudel, S., Lee, T., Yan, C., Tan, M., Kim, K.M., Cho, S.S., Ki, S.H., Huang, H., Zhao, Y., Lee, S. (2023). Identification of Histone Lysine Acetoacetylation as a Dynamic Post-Translational Modification Regulated by HB01. Advanced Science.

3. Song, B., Sheng, X.*, Justice, J.L., Lum, K.K., Metzger, P.J., Cook, K.C., Kostas, J.C., Cristea, I.M. (2023). Intercellular communication within the virus microenvironment affects the susceptibility of cells to secondary viral infections. Science Advances.

4. Shi, W., Sheng, X.*, Dorr, K.M., Hutton, J.E., Emerson, J.I., Davies, H.A., Andrade, T.D., Wasson, L.K., Greco, T.M., Hashimoto, Y., Federspiel, J.D., Robbe, Z.L., Chen, X., Arnold, A.P., Cristea, I.M., Conlon, F.L. (2021). Cardiac proteomics reveals sex chromosome-dependent differences between males and females that arise prior to gonad formation. Developmental Cell.

5. Sheng, X., Cristea, I.M. (2021). The antiviral sirtuin 3 bridges protein acetylation to mitochondrial integrity and metabolism during human cytomegalovirus infection. PLoS Pathogens.